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Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations

We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair....

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Main Authors: Guimarães, Maria de Nazaré Klautau, D’Ascenção, Renata, Caldart, Fabiana A., Grisolia, Cesar Koppe, Souza, Jurandir R. de, Barbosa, Antonio C., Cordeiro, Célia M. T., Ferrari, Iris
Format: Artigo
Language: Inglês
Published: Sociedade Brasileira de Genética 2017
Subjects:
Índios
Polimorfismo (Genética)
Mercúrio (Hg)
Online Access: http://repositorio.unb.br/handle/10482/24885
http://dx.doi.org/10.1590/S1415-47572005000500027
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spelling ir-10482-248852021-03-12T11:46:58Z Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations Guimarães, Maria de Nazaré Klautau D’Ascenção, Renata Caldart, Fabiana A. Grisolia, Cesar Koppe Souza, Jurandir R. de Barbosa, Antonio C. Cordeiro, Célia M. T. Ferrari, Iris Índios Polimorfismo (Genética) Mercúrio (Hg) We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of two villages in the Kayabi and Munduruku Amerindian communities to investigate mercury levels in association with genetic polymorphism of GSTs. Other molecular biological markers were also studied, such as hemoglobin, haptoglobin and glucose 6-phosphate dehydrogenase (G-6-PDH). Higher levels of mercury contamination were found in the Kayabi villagers, who had a null genotype (GSTM1 0/0, also denominated GSTM1 null) frequency of 26%, than in the Munduruku villagers, for which the null genotype frequency was 0%. Individuals with the GSTM1 null phenotype had higher concentrations of mercury in their hair than individuals with GSTM1+/+ phenotypes (F = 21.51, p < 0.0001). No association with other markers studied was observed. This study suggests that GSTM1 may be involved in the biotransformation of mercury in humans. 2017-10-25T14:45:56Z 2017-10-25T14:45:56Z 2005-12 Artigo GUIMARÃES, Maria de Nazaré Klautau et al. Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations. Genetics and Molecular Biology, São Paulo, v. 28, n. 4, p. 827-832, dez. 2005. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500027&lng=en&nrm=iso>. Acesso em: 24 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572005000500027. http://repositorio.unb.br/handle/10482/24885 http://dx.doi.org/10.1590/S1415-47572005000500027 Inglês Acesso Aberto Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500027&lng=en&nrm=iso. Acesso em: 24 out. 2017. application/pdf Sociedade Brasileira de Genética
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Índios
Polimorfismo (Genética)
Mercúrio (Hg)
spellingShingle Índios
Polimorfismo (Genética)
Mercúrio (Hg)
Guimarães, Maria de Nazaré Klautau
D’Ascenção, Renata
Caldart, Fabiana A.
Grisolia, Cesar Koppe
Souza, Jurandir R. de
Barbosa, Antonio C.
Cordeiro, Célia M. T.
Ferrari, Iris
Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
description We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of two villages in the Kayabi and Munduruku Amerindian communities to investigate mercury levels in association with genetic polymorphism of GSTs. Other molecular biological markers were also studied, such as hemoglobin, haptoglobin and glucose 6-phosphate dehydrogenase (G-6-PDH). Higher levels of mercury contamination were found in the Kayabi villagers, who had a null genotype (GSTM1 0/0, also denominated GSTM1 null) frequency of 26%, than in the Munduruku villagers, for which the null genotype frequency was 0%. Individuals with the GSTM1 null phenotype had higher concentrations of mercury in their hair than individuals with GSTM1+/+ phenotypes (F = 21.51, p < 0.0001). No association with other markers studied was observed. This study suggests that GSTM1 may be involved in the biotransformation of mercury in humans.
format Artigo
author Guimarães, Maria de Nazaré Klautau
D’Ascenção, Renata
Caldart, Fabiana A.
Grisolia, Cesar Koppe
Souza, Jurandir R. de
Barbosa, Antonio C.
Cordeiro, Célia M. T.
Ferrari, Iris
author_sort Guimarães, Maria de Nazaré Klautau
title Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
title_short Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
title_full Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
title_fullStr Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
title_full_unstemmed Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
title_sort analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk amazon amerindian populations
publisher Sociedade Brasileira de Genética
publishDate 2017
url http://repositorio.unb.br/handle/10482/24885
http://dx.doi.org/10.1590/S1415-47572005000500027
_version_ 1695119539322224640
score 13.657419

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