Staff View: Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera

Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera

In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitox...

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Main Authors:	Santana, A.N.C., Trindade-Filho, E.M., Cunha, R.B., Sousa, M.V., Cavalheiro, E.A., Carvalho, K.M.
Format:	Artigo
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2017
Subjects:	Bunodosoma granulifera granulitoxin sea anemones toxic peptides seizure electroencephalographic assay
Online Access:	http://repositorio.unb.br/handle/10482/25734
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spelling	ir-10482-257342019-03-28T14:04:08Z Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera Santana, A.N.C. Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M. Bunodosoma granulifera granulitoxin sea anemones toxic peptides seizure electroencephalographic assay In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitoxin (8 µg) into the dorsal hippocampus and consisted of seizure activity that began in the hippocampus and spread rapidly to the occipital cortex. This activity lasted 20-30 s, and during this period the rats presented immobility. During the first 40-50 min after its administration, three to four other similar short EEG seizure periods occurred and the rats presented the following behavioral alterations: akinesia, facial automatisms, head tremor, salivation, rearing, jumping, barrel-rolling, wet dog shakes and forelimb clonic movements. Within 40-50 min, the status epilepticus was established and lasted 8-12 h. These results are similar to those observed in the acute phase of the pilocarpine model of temporal lobe epilepsy and suggest that granulitoxin may be a useful tool not only to study the sodium channels, but also to develop a new experimental model of status epilepticus. 2017-12-07T04:33:56Z 2017-12-07T04:33:56Z 2001 Artigo Braz J Med Biol Res,v.34,n.6,p.797-801,2001 0100-879X http://repositorio.unb.br/handle/10482/25734 10.1590/S0100-879X2001000600016 en Acesso Aberto application/pdf Associação Brasileira de Divulgação Científica http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600016&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2001000600016&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-879X2001000600016&lng=en&nrm=iso
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Bunodosoma granulifera granulitoxin sea anemones toxic peptides seizure electroencephalographic assay
spellingShingle	Bunodosoma granulifera granulitoxin sea anemones toxic peptides seizure electroencephalographic assay Santana, A.N.C. Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M. Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
description	In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitoxin (8 µg) into the dorsal hippocampus and consisted of seizure activity that began in the hippocampus and spread rapidly to the occipital cortex. This activity lasted 20-30 s, and during this period the rats presented immobility. During the first 40-50 min after its administration, three to four other similar short EEG seizure periods occurred and the rats presented the following behavioral alterations: akinesia, facial automatisms, head tremor, salivation, rearing, jumping, barrel-rolling, wet dog shakes and forelimb clonic movements. Within 40-50 min, the status epilepticus was established and lasted 8-12 h. These results are similar to those observed in the acute phase of the pilocarpine model of temporal lobe epilepsy and suggest that granulitoxin may be a useful tool not only to study the sodium channels, but also to develop a new experimental model of status epilepticus.
format	Artigo
author	Santana, A.N.C. Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M.
author_sort	Santana, A.N.C.
title	Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
title_short	Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
title_full	Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
title_fullStr	Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
title_full_unstemmed	Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
title_sort	behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone bunodosoma granulifera
publisher	Associação Brasileira de Divulgação Científica
publishDate	2017
url	http://repositorio.unb.br/handle/10482/25734
_version_	1641988718668546048
score	13.657419

Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera

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