Staff View: Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects

Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects

OBJECTIVE:To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-speci...

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Main Authors:	Barra, Gustavo Barcelos, Dutra, Ludmila Alves Sanches, Watanabe, Sílvia Conde, Costa, Patrícia Godoy Garcia, Cruz, Patrícia Sales Marques da, Azevedo, Monalisa Ferreira, Amato, Angélica Amorim
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira de Endocrinologia e Metabologia 2017
Subjects:	TCF7L2 single nucleotide polymorphism type 2 diabetes rs7903146 Polimorfismo de nucleotídeo único diabetes tipo 2
Online Access:	http://repositorio.unb.br/handle/10482/28262
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spelling	ir-10482-282622019-03-28T14:02:44Z Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects Associação do polimorfismo de nucleotídeo único rs7903146 no locus do TCF7L2 com diabetes tipo 2 em indivíduos brasileiros Barra, Gustavo Barcelos Dutra, Ludmila Alves Sanches Watanabe, Sílvia Conde Costa, Patrícia Godoy Garcia Cruz, Patrícia Sales Marques da Azevedo, Monalisa Ferreira Amato, Angélica Amorim TCF7L2 single nucleotide polymorphism type 2 diabetes rs7903146 TCF7L2 Polimorfismo de nucleotídeo único diabetes tipo 2 rs7903146 OBJECTIVE:To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. RESULTS:We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). CONCLUSION:These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds. Arq Bras Endocrinol Metab. 2012;56(8):479-84 OBJETIVO: Investigar a associação do alelo T do polimorfismo de nucleotídeo único (SNP) rs7903146 do TCF7L2 com a ocorrência de DM2 em uma amostra de indivíduos acompanhados no Hospital Universitário de Brasília. SUJEITOS E MÉTODOS: O SNP 7903146 do TCF7L2 foi genotipado por PCR alelo-específica em 113 pacientes portadores de DM2 e em 139 controles não diabéticos em Brasília, Brasil. RESULTADOS: Foi observada associação significativa do alelo T do SNP rs7903146 do TCF7L2 com a ocorrência de DM2 (razão de chances de 3,92 para o genótipo TT utilizando o modelo genético recessivo, p = 0,003; e de 1,5 para o alelo T, p = 0,032). CONCLUSÃO: Esse resultado reforça os achados prévios de associação consistente desse fator genético com o risco de diabetes em populações de origens étnicas diversas. Arq Bras Endocrinol Metab. 2012;56(8):479-84 2017-12-07T04:58:03Z 2017-12-07T04:58:03Z 2012 Artigo Arq Bras Endocrinol Metab,v.56,n.8,p.479-484,2012 0004-2730 http://repositorio.unb.br/handle/10482/28262 10.1590/S0004-27302012000800003 en Acesso Aberto application/pdf Sociedade Brasileira de Endocrinologia e Metabologia http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000800003&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000800003&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-27302012000800003&lng=en&nrm=iso
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	TCF7L2 single nucleotide polymorphism type 2 diabetes rs7903146 TCF7L2 Polimorfismo de nucleotídeo único diabetes tipo 2 rs7903146
spellingShingle	TCF7L2 single nucleotide polymorphism type 2 diabetes rs7903146 TCF7L2 Polimorfismo de nucleotídeo único diabetes tipo 2 rs7903146 Barra, Gustavo Barcelos Dutra, Ludmila Alves Sanches Watanabe, Sílvia Conde Costa, Patrícia Godoy Garcia Cruz, Patrícia Sales Marques da Azevedo, Monalisa Ferreira Amato, Angélica Amorim Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
description	OBJECTIVE:To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. SUBJECTS AND METHODS: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. RESULTS:We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). CONCLUSION:These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds. Arq Bras Endocrinol Metab. 2012;56(8):479-84
format	Artigo
author	Barra, Gustavo Barcelos Dutra, Ludmila Alves Sanches Watanabe, Sílvia Conde Costa, Patrícia Godoy Garcia Cruz, Patrícia Sales Marques da Azevedo, Monalisa Ferreira Amato, Angélica Amorim
author_sort	Barra, Gustavo Barcelos
title	Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
title_short	Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
title_full	Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
title_fullStr	Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
title_full_unstemmed	Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects
title_sort	association of the rs7903146 single nucleotide polymorphism at the transcription factor 7-like 2 (tcf7l2) locus with type 2 diabetes in brazilian subjects
publisher	Sociedade Brasileira de Endocrinologia e Metabologia
publishDate	2017
url	http://repositorio.unb.br/handle/10482/28262
_version_	1641988223027642368
score	13.657419

Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects

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