Staff View: Occurrence of dolichocolon without megacolon in chronic Chagas disease patients

Occurrence of dolichocolon without megacolon in chronic Chagas disease patients

INTRODUCTION: Since 1970, lengthening of the rectosigmoid has been suspected to be a solitary manifestation of Chagas colopathy. METHODS: To test this hypothesis, opaque enema was administered on 210 seropositive and 63 seronegative patients, and radiographs in the anteroposterior and posteroanterio...

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Main Authors:	Castro, Cleudson, Hernandez, Esperanza Bernal, Rezende, Joffre, Prata, Aluizio
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2017
Subjects:	Dolichocolon Solitary dolichocolon Chagas disease Lengthening of the sigmoid Length of the sigmoid Dolicocólon Dolicocólon solitário Doença de Chagas Alongamento do sigmoide Comprimento do sigmoide
Online Access:	http://repositorio.unb.br/handle/10482/28294
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spelling	ir-10482-282942019-03-28T14:02:45Z Occurrence of dolichocolon without megacolon in chronic Chagas disease patients Ocorrência de dolicocólon sem megacólon em chagásicos crônicos Castro, Cleudson Hernandez, Esperanza Bernal Rezende, Joffre Prata, Aluizio Dolichocolon Solitary dolichocolon Chagas disease Lengthening of the sigmoid Length of the sigmoid Dolicocólon Dolicocólon solitário Doença de Chagas Alongamento do sigmoide Comprimento do sigmoide INTRODUCTION: Since 1970, lengthening of the rectosigmoid has been suspected to be a solitary manifestation of Chagas colopathy. METHODS: To test this hypothesis, opaque enema was administered on 210 seropositive and 63 seronegative patients, and radiographs in the anteroposterior and posteroanterior positions were examined blind to the serological and clinical findings. The distal colon was measured using a flexible ruler along the central axis of the image from the anus to the iliac crest. RESULTS: Dolichocolon was diagnosed in 31 (14.8%) seropositive and 3 (4.8%) seronegative patients. The mean length was 57.2 (±12.2)cm in seropositive patients and 52.1 (±8.8)cm in the seronegative patients (p = 0.000), that is, the distal colon in Chagas patients was, on average, 5.1cm longer. Seropositive female patients presented a mean length of 58.8 (±12.3)cm, and seronegative female patients presented 53.2 (±9.1)cm (p = 0.002). Seropositive male patients had a mean length of 55 (±11.6)cm, and seronegative male patients had 49.9 (±7.8)cm (p = 0.02). Among 191 patients without megacolon and suspected megacolon, the mean length was 56.3 (±11.6)cm in seropositive individuals and 52 (±8.8)cm in seronegative patients (p = 0.003). Among individuals with distal colon >70cm, there were 31 Chagas patients with mean length of 77.9 (±7.1)cm and three seronegative with 71.3 (±1.1)cm (p = 0.000). Among 179 with distal colon <70cm, seropositive individuals had a mean length of 53.6 (±8.8)cm, and seronegative patients had 51.2 (±7.8)cm (p = 0.059). Serological positive women had longer distal colon than men (p = 0.02), whereas the mean length were the same among seronegative individuals (p = 0.16). CONCLUSIONS: In endemic areas of Brazil Central, solitary dolichocolon is a radiological Chagas disease signal. INTRODUÇÃO: Desde 1970, suspeita-se que o alongamento do retossigmoide pode ocorrer como manifestação isolada da colopatia chagásica. MÉTODOS: Para testar esta hipótese, 210 pacientes soropositivos e 63 soronegativos fizeram enema opaco e as radiografias nas posições ântero-posterior e póstero-anterior foram lidas sem conhecimento dos dados clínicos e sorológicos. O comprimento do cólon distal foi medido com curvímetro, percorrendo-se o eixo central da imagem, do ânus à crista ilíaca. RESULTADOS: O diagnóstico de dolicocólon foi estabelecido em 31 (14,8%) pacientes soropositivos e 3 (4,8%) soronegativos. O comprimento médio nos pacientes soropositivos foi de 57,2 (±12,2)cm, enquanto nos soronegativos foi de 52,1 (±8,8)cm (p=0,000), isto é, os chagásicos apresentaram o cólon distal em média 5,1cm maior. Os indivíduos do sexo feminino soropositivos exibiram comprimento médio de 58,8 (±12,3)cm, e os soronegativos de 53,2 (±9,1)cm, (p=0,002). Nos pacientes do sexo masculino soropositivos, o comprimento médio foi de 55 (±11,6)cm, enquanto nos soronegativos foi de 49,9 (±7,8)cm (p=0,02). Nos 191 pacientes, sem megacólon e suspeitos de megacólon, o comprimento médio foi de 56,3 (±11,6)cm nos soropostivos e 52 (±8,8)cm nos soronegativos (p=0,003). Dos indivíduos com cólon distal >70cm, os 31 chagásicos tiveram comprimento médio de 77,9 (±7,1)cm, enquanto nos três não chagásicos foi de 71,3 (±1,1)cm, (p=0,000). Nos 179 com cólon distal <70cm, os soropositivos tiveram em média 53,6 (±8,8)cm, e os soronegativos 51,2 (±7,8)cm, (p=0,059). Dentre os com sorologia positiva, as mulheres apresentaram cólon distal maior que os homens (p=0,02), enquanto naqueles com sorologia negativa o comprimento médio foi igual (p=0,16). CONCLUSÕES: Nas áreas endêmicas do Brasil Central, o dolicocólon solitário é um sinal radiológico da doença de Chagas. 2017-12-07T04:58:11Z 2017-12-07T04:58:11Z 2012 Artigo Rev. Soc. Bras. Med. Trop.,v.45,n.3,p.353-356,2012 0037-8682 http://repositorio.unb.br/handle/10482/28294 10.1590/S0037-86822012000300014 en Acesso Aberto application/pdf Sociedade Brasileira de Medicina Tropical - SBMT http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300014&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86822012000300014&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0037-86822012000300014&lng=en&nrm=iso
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Dolichocolon Solitary dolichocolon Chagas disease Lengthening of the sigmoid Length of the sigmoid Dolicocólon Dolicocólon solitário Doença de Chagas Alongamento do sigmoide Comprimento do sigmoide
spellingShingle	Dolichocolon Solitary dolichocolon Chagas disease Lengthening of the sigmoid Length of the sigmoid Dolicocólon Dolicocólon solitário Doença de Chagas Alongamento do sigmoide Comprimento do sigmoide Castro, Cleudson Hernandez, Esperanza Bernal Rezende, Joffre Prata, Aluizio Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
description	INTRODUCTION: Since 1970, lengthening of the rectosigmoid has been suspected to be a solitary manifestation of Chagas colopathy. METHODS: To test this hypothesis, opaque enema was administered on 210 seropositive and 63 seronegative patients, and radiographs in the anteroposterior and posteroanterior positions were examined blind to the serological and clinical findings. The distal colon was measured using a flexible ruler along the central axis of the image from the anus to the iliac crest. RESULTS: Dolichocolon was diagnosed in 31 (14.8%) seropositive and 3 (4.8%) seronegative patients. The mean length was 57.2 (±12.2)cm in seropositive patients and 52.1 (±8.8)cm in the seronegative patients (p = 0.000), that is, the distal colon in Chagas patients was, on average, 5.1cm longer. Seropositive female patients presented a mean length of 58.8 (±12.3)cm, and seronegative female patients presented 53.2 (±9.1)cm (p = 0.002). Seropositive male patients had a mean length of 55 (±11.6)cm, and seronegative male patients had 49.9 (±7.8)cm (p = 0.02). Among 191 patients without megacolon and suspected megacolon, the mean length was 56.3 (±11.6)cm in seropositive individuals and 52 (±8.8)cm in seronegative patients (p = 0.003). Among individuals with distal colon >70cm, there were 31 Chagas patients with mean length of 77.9 (±7.1)cm and three seronegative with 71.3 (±1.1)cm (p = 0.000). Among 179 with distal colon <70cm, seropositive individuals had a mean length of 53.6 (±8.8)cm, and seronegative patients had 51.2 (±7.8)cm (p = 0.059). Serological positive women had longer distal colon than men (p = 0.02), whereas the mean length were the same among seronegative individuals (p = 0.16). CONCLUSIONS: In endemic areas of Brazil Central, solitary dolichocolon is a radiological Chagas disease signal.
format	Artigo
author	Castro, Cleudson Hernandez, Esperanza Bernal Rezende, Joffre Prata, Aluizio
author_sort	Castro, Cleudson
title	Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
title_short	Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
title_full	Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
title_fullStr	Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
title_full_unstemmed	Occurrence of dolichocolon without megacolon in chronic Chagas disease patients
title_sort	occurrence of dolichocolon without megacolon in chronic chagas disease patients
publisher	Sociedade Brasileira de Medicina Tropical - SBMT
publishDate	2017
url	http://repositorio.unb.br/handle/10482/28294
_version_	1641988359994736640
score	13.657419

Occurrence of dolichocolon without megacolon in chronic Chagas disease patients

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