Staff View: Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence

Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence

We aimed to assess and synthesize the information available in the literature regarding the treatment of American tegumentary leishmaniasis in special populations. We searched MEDLINE (via PubMed), EMBASE, LILACS, SciELO, Scopus, Cochrane Library and mRCT databases to identify clinical trials and ob...

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Main Authors:	Silva, Juliana Saboia Fontenele e, Galvão, Taís Freire, Pereira, Maurício Gomes, Silva, Marcus Tolentino
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2017
Subjects:	Leishmaniose tegumentar americana Populações especiais Leishmaniose - tratamento
Online Access:	http://repositorio.unb.br/handle/10482/28692 https://dx.doi.org/10.1590/0037-8682-0104-2013
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spelling	ir-10482-286922020-09-17T10:46:00Z Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence Silva, Juliana Saboia Fontenele e Galvão, Taís Freire Pereira, Maurício Gomes Silva, Marcus Tolentino Leishmaniose tegumentar americana Populações especiais Leishmaniose - tratamento We aimed to assess and synthesize the information available in the literature regarding the treatment of American tegumentary leishmaniasis in special populations. We searched MEDLINE (via PubMed), EMBASE, LILACS, SciELO, Scopus, Cochrane Library and mRCT databases to identify clinical trials and observational studies that assessed the pharmacological treatment of the following groups of patients: pregnant women, nursing mothers, children, the elderly, individuals with chronic diseases and individuals with suppressed immune systems. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The available evidence suggests that the treatments of choice for each population or disease entity are as follows: nursing mothers and children (meglumine antimoniate or pentamidine), patients with renal disease (amphotericin B or miltefosine), patients with heart disease (amphotericin B, miltefosine or pentamidine), immunosuppressed patients (liposomal amphotericin), the elderly (meglumine antimoniate), pregnant women (amphotericin B) and patients with liver disease (no evidence available). The quality of evidence is low or very low for all groups. Accurate controlled studies are required to fill in the gaps in evidence for treatment in special populations. Post-marketing surveillance programs could also collect relevant information to guide treatment decision-making. 2017-12-07T05:02:25Z 2017-12-07T05:02:25Z 2013-12 Artigo SILVA, Juliana Saboia Fontenele e et al. Treatment of American tegumentary leishmaniasis in special populations: a summary of evidence. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 6, p. 669-677, nov./dez. 2013. DOI: https://doi.org/10.1590/0037-8682-0104-2013. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000600669&lng=en&tlng=en. Acesso em: 14 set. 2020. http://repositorio.unb.br/handle/10482/28692 https://dx.doi.org/10.1590/0037-8682-0104-2013 en Acesso Aberto Revista da Sociedade Brasileira de Medicina Tropical - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000600669&lng=en&tlng=en. Acesso em: 14 set. 2020. application/pdf Sociedade Brasileira de Medicina Tropical - SBMT
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Leishmaniose tegumentar americana Populações especiais Leishmaniose - tratamento
spellingShingle	Leishmaniose tegumentar americana Populações especiais Leishmaniose - tratamento Silva, Juliana Saboia Fontenele e Galvão, Taís Freire Pereira, Maurício Gomes Silva, Marcus Tolentino Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
description	We aimed to assess and synthesize the information available in the literature regarding the treatment of American tegumentary leishmaniasis in special populations. We searched MEDLINE (via PubMed), EMBASE, LILACS, SciELO, Scopus, Cochrane Library and mRCT databases to identify clinical trials and observational studies that assessed the pharmacological treatment of the following groups of patients: pregnant women, nursing mothers, children, the elderly, individuals with chronic diseases and individuals with suppressed immune systems. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The available evidence suggests that the treatments of choice for each population or disease entity are as follows: nursing mothers and children (meglumine antimoniate or pentamidine), patients with renal disease (amphotericin B or miltefosine), patients with heart disease (amphotericin B, miltefosine or pentamidine), immunosuppressed patients (liposomal amphotericin), the elderly (meglumine antimoniate), pregnant women (amphotericin B) and patients with liver disease (no evidence available). The quality of evidence is low or very low for all groups. Accurate controlled studies are required to fill in the gaps in evidence for treatment in special populations. Post-marketing surveillance programs could also collect relevant information to guide treatment decision-making.
format	Artigo
author	Silva, Juliana Saboia Fontenele e Galvão, Taís Freire Pereira, Maurício Gomes Silva, Marcus Tolentino
author_sort	Silva, Juliana Saboia Fontenele e
title	Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
title_short	Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
title_full	Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
title_fullStr	Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
title_full_unstemmed	Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence
title_sort	treatment of american tegumentary leishmaniasis in special populations : a summary of evidence
publisher	Sociedade Brasileira de Medicina Tropical - SBMT
publishDate	2017
url	http://repositorio.unb.br/handle/10482/28692 https://dx.doi.org/10.1590/0037-8682-0104-2013
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score	13.657419

Treatment of American tegumentary leishmaniasis in special populations : a summary of evidence

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