Staff View: The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL

The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL

INTRODUCTION: Enhanced inflammatory-oxidative status is well established in chronic kidney disease. OBJECTIVE: The objective of this study was to evaluate the oxidative- inflammatory status and iron indices in patients undergoing maintenance hemodialysis (HD) with serum ferritin lower than 500ng/mL,...

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Main Authors:	Almeida, Simone Gonçalves de, Veiga, Joel Paulo Russomano, Arruda, Sandra Fernandes, Neves, Cibele Ferreira, Siqueira, Egle Machado de Almeida
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira de Nefrologia 2017
Subjects:	Diálise renal Estado nutricional Estresse oxidativo Ferro na dieta Inflamação
Online Access:	http://repositorio.unb.br/handle/10482/28741 https://dx.doi.org/10.5935/01012800.20130002
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spelling	ir-10482-287412020-10-22T16:16:43Z The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL Associação dos marcadores do estado oxidativo e inflamatório com a desnutrição em pacientes hemodialisados com ferritina menor do que 500 ng/mL Almeida, Simone Gonçalves de Veiga, Joel Paulo Russomano Arruda, Sandra Fernandes Neves, Cibele Ferreira Siqueira, Egle Machado de Almeida Diálise renal Estado nutricional Estresse oxidativo Ferro na dieta Inflamação INTRODUCTION: Enhanced inflammatory-oxidative status is well established in chronic kidney disease. OBJECTIVE: The objective of this study was to evaluate the oxidative- inflammatory status and iron indices in patients undergoing maintenance hemodialysis (HD) with serum ferritin lower than 500ng/mL, and to correlate them with nutritional status. METHOD: In a cross-sectional survey 35 HD patients (23 with normal nutritional status, 12 with Protein-Energy-Wasting syndrome, PEW), and healthy volunteers (n = 35) were studied. Serum concentration of iron, ferritin, transferrin saturation, malondialdehyde (MDA), protein carbonyl (PC), high-sensitive serum C -reactive protein (hs-CRP) and blood counts were determined. The nutritional status was determined by anthropometric and biochemical criteria. RESULTS: HD patients showed low values of hemoglobin and higher values of ferritin, MDA and PC when compared with healthy volunteers. HD subjects with PEW had higher values of PC and hs-PCR as compared to HD patients with normal nutritional status. A multiple logistic regression analysis showed that the independent variables PC (Wald Statistic 4.25, p = 0.039) and hs-CRP (Wald Statistic 4.83, p = 0.028) where related with the patients' nutritional condition. CONCLUSION: In HD patients with serum ferritin below 500 ng/mL was observed one association of the markers of oxidative stress and inflammation with poor nutritional status independently of serum ferritin, gender and age. INTRODUÇÃO: Na doença renal crônica, a presença de um estado inflamatório-oxidativo aumentado está bem estabelecida. OBJETIVO: O objetivo do presente estudo foi avaliar o estado oxidativo e inflamatório e o perfil do ferro em pacientes submetidos à hemodiálise crônica de manutenção, com ferritina menor do que 500 ng/mL, e correlacioná-los com o estado nutricional. MÉTODO: Em estudo transversal, em 35 pacientes sob hemodiálise (23 com estado nutricional normal, 12 com desnutrição energético-proteica (DEP) e 35 voluntários sadios foram determinados os índices hematimétricos e as concentrações séricas do ferro, da ferritina e avaliada a saturação de transferrina. O estado oxidativo foi determinado por meio das concentrações séricas do malondialdeído (MDA) e da proteína carbonil (PC). Nos indivíduos sob hemodiálise o estado inflamatório foi avaliado por meio da proteína C reativa ultrassensível determinada no soro (hs-PCR). O estado nutricional foi determinado por critérios antropométricos e bioquímicos. RESULTADOS: Os pacientes da hemodiálise mostraram anemia e um estado oxidativo mais elevado do que os voluntários sadios. Os pacientes hemodialisados com DPE mostraram ferritina e um estado inflamatório-oxidativo mais elevado se comparados aos com boa condição nutricional. Em análise de regressão logística múltipla, os níveis séricos de PC e hs-CRP foram correlacionados com o estado nutricional. PC (Estatística Wald 4.25, p = 0,039), CRP (Estatística Wald 4.83, p = 0,028). CONCLUSÃO: Em indivíduos submetidos à hemodiálise, com ferritina menor do que 500 ng/mL. Observou-se uma associação entre os marcadores de estresse oxidativo e inflamatório com o estado nutricional, independentemente da idade, gênero e dos índices do ferro. 2017-12-07T05:02:34Z 2017-12-07T05:02:34Z 2013 Artigo J. Bras. Nefrol.,v.35,n.1,p.6-12,2013 http://repositorio.unb.br/handle/10482/28741 https://dx.doi.org/10.5935/01012800.20130002 en Acesso Aberto application/pdf Sociedade Brasileira de Nefrologia
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Diálise renal Estado nutricional Estresse oxidativo Ferro na dieta Inflamação
spellingShingle	Diálise renal Estado nutricional Estresse oxidativo Ferro na dieta Inflamação Almeida, Simone Gonçalves de Veiga, Joel Paulo Russomano Arruda, Sandra Fernandes Neves, Cibele Ferreira Siqueira, Egle Machado de Almeida The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
description	INTRODUCTION: Enhanced inflammatory-oxidative status is well established in chronic kidney disease. OBJECTIVE: The objective of this study was to evaluate the oxidative- inflammatory status and iron indices in patients undergoing maintenance hemodialysis (HD) with serum ferritin lower than 500ng/mL, and to correlate them with nutritional status. METHOD: In a cross-sectional survey 35 HD patients (23 with normal nutritional status, 12 with Protein-Energy-Wasting syndrome, PEW), and healthy volunteers (n = 35) were studied. Serum concentration of iron, ferritin, transferrin saturation, malondialdehyde (MDA), protein carbonyl (PC), high-sensitive serum C -reactive protein (hs-CRP) and blood counts were determined. The nutritional status was determined by anthropometric and biochemical criteria. RESULTS: HD patients showed low values of hemoglobin and higher values of ferritin, MDA and PC when compared with healthy volunteers. HD subjects with PEW had higher values of PC and hs-PCR as compared to HD patients with normal nutritional status. A multiple logistic regression analysis showed that the independent variables PC (Wald Statistic 4.25, p = 0.039) and hs-CRP (Wald Statistic 4.83, p = 0.028) where related with the patients' nutritional condition. CONCLUSION: In HD patients with serum ferritin below 500 ng/mL was observed one association of the markers of oxidative stress and inflammation with poor nutritional status independently of serum ferritin, gender and age.
format	Artigo
author	Almeida, Simone Gonçalves de Veiga, Joel Paulo Russomano Arruda, Sandra Fernandes Neves, Cibele Ferreira Siqueira, Egle Machado de Almeida
author_sort	Almeida, Simone Gonçalves de
title	The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
title_short	The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
title_full	The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
title_fullStr	The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
title_full_unstemmed	The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL
title_sort	association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/ml
publisher	Sociedade Brasileira de Nefrologia
publishDate	2017
url	http://repositorio.unb.br/handle/10482/28741 https://dx.doi.org/10.5935/01012800.20130002
_version_	1682348209092952064
score	13.657419

The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL

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