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Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats

PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subc...

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Main Authors: Penhavel, Maria Vitória Carmo, Nascimento, Victor Henrique Tavares, Durães, Eliana Ferreira Ribeiro, Carneiro, Fabiana Pirani, Sousa, João Batista de
Format: Artigo
Language: English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2017
Subjects:
Cura
Dióxido de carbono
Pele
Ratos
Online Access: http://repositorio.unb.br/handle/10482/28801
https://dx.doi.org/10.1590/S0102-86502013000500003
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spelling ir-10482-288012021-01-22T18:07:46Z Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats Penhavel, Maria Vitória Carmo Nascimento, Victor Henrique Tavares Durães, Eliana Ferreira Ribeiro Carneiro, Fabiana Pirani Sousa, João Batista de Cura Dióxido de carbono Pele Ratos PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats. 2017-12-07T05:02:47Z 2017-12-07T05:02:47Z 2013-05 Artigo PENHAVEL, Maria Vitória Carmo et al. Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 5, p. 334-339, maio 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000500003. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&nrm=iso. Acesso em: 04 dez. 2020. http://repositorio.unb.br/handle/10482/28801 https://dx.doi.org/10.1590/S0102-86502013000500003 en Acesso Aberto Acta Cirúrgica Brasileira - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000500003&lng=en&tlng=en. Acesso em: 04 dez. 2020. application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language English
topic Cura
Dióxido de carbono
Pele
Ratos
spellingShingle Cura
Dióxido de carbono
Pele
Ratos
Penhavel, Maria Vitória Carmo
Nascimento, Victor Henrique Tavares
Durães, Eliana Ferreira Ribeiro
Carneiro, Fabiana Pirani
Sousa, João Batista de
Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
description PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
format Artigo
author Penhavel, Maria Vitória Carmo
Nascimento, Victor Henrique Tavares
Durães, Eliana Ferreira Ribeiro
Carneiro, Fabiana Pirani
Sousa, João Batista de
author_sort Penhavel, Maria Vitória Carmo
title Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_short Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_fullStr Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_full_unstemmed Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
title_sort effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate 2017
url http://repositorio.unb.br/handle/10482/28801
https://dx.doi.org/10.1590/S0102-86502013000500003
_version_ 1690679506414600192
score 13.657419

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