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Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial

The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patie...

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Main Authors: Braz, Alessandra Sousa, Morais, Liana Clébia S., Paula, Ana Patrícia de, Diniz, Margareth F. F. M., Almeida, Reinaldo N.
Format: Artigo
Language: English
Published: Associação Brasileira de Psiquiatria - ABP 2017
Subjects:
Fibromialgia
Ginseng
Farmacologia
Tratamento complementar
Fitoterapia
Online Access: http://repositorio.unb.br/handle/10482/28983
https://dx.doi.org/10.1016/j.rbp.2013.01.004
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spelling ir-10482-289832020-08-12T14:20:07Z Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial Braz, Alessandra Sousa Morais, Liana Clébia S. Paula, Ana Patrícia de Diniz, Margareth F. F. M. Almeida, Reinaldo N. Fibromialgia Ginseng Farmacologia Tratamento complementar Fitoterapia The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to anxiety, improvements occurred in the P. ginseng group compared to baseline (p < .0001); however, amitriptyline treatment resulted in significantly greater improvements (p < .05). P. ginseng reduced the number of tender points and improved patients' quality of life (using the Fibromyalgia Impact Questionnaire - FIQ); however, there were no differences between groups. The beneficial effects experienced by patients for all parameters suggest a need for further studies to be performed on the tolerability and efficacy of this phytotherapic as a complementary therapy for fibromyalgia. 2017-12-07T05:03:49Z 2017-12-07T05:03:49Z 2013-03 Artigo BRAZ, Alessandra Sousa et al. Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial. Brazilian Journal of Psychiatry, São Paulo, v. 35, n. 1, p. 21-28, mar. 2013. DOI: http://dx.doi.org/10.1016/j.rbp.2013.01.004. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005. Acesso em: 06 ago. 2020. http://repositorio.unb.br/handle/10482/28983 https://dx.doi.org/10.1016/j.rbp.2013.01.004 en Acesso Aberto Brazilian Journal of Psychiatry - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005. Acesso em: 06 ago. 2020. application/pdf Associação Brasileira de Psiquiatria - ABP
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language English
topic Fibromialgia
Ginseng
Farmacologia
Tratamento complementar
Fitoterapia
spellingShingle Fibromialgia
Ginseng
Farmacologia
Tratamento complementar
Fitoterapia
Braz, Alessandra Sousa
Morais, Liana Clébia S.
Paula, Ana Patrícia de
Diniz, Margareth F. F. M.
Almeida, Reinaldo N.
Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
description The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to anxiety, improvements occurred in the P. ginseng group compared to baseline (p < .0001); however, amitriptyline treatment resulted in significantly greater improvements (p < .05). P. ginseng reduced the number of tender points and improved patients' quality of life (using the Fibromyalgia Impact Questionnaire - FIQ); however, there were no differences between groups. The beneficial effects experienced by patients for all parameters suggest a need for further studies to be performed on the tolerability and efficacy of this phytotherapic as a complementary therapy for fibromyalgia.
format Artigo
author Braz, Alessandra Sousa
Morais, Liana Clébia S.
Paula, Ana Patrícia de
Diniz, Margareth F. F. M.
Almeida, Reinaldo N.
author_sort Braz, Alessandra Sousa
title Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
title_short Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
title_full Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
title_fullStr Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
title_full_unstemmed Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
title_sort effects of panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
publisher Associação Brasileira de Psiquiatria - ABP
publishDate 2017
url http://repositorio.unb.br/handle/10482/28983
https://dx.doi.org/10.1016/j.rbp.2013.01.004
_version_ 1675464109195264000
score 13.657419

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