Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the eff...
| Main Authors: | Vieira, Michele Juliane, Perosa, Sandra Regina, Argañaraz, Gustavo Adolfo, Silva Junior, José Antônio, Cavalheiro, Esper Abrão, Naffah-Mazzacoratti, Maria da Graça |
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| Format: | Artigo |
| Language: | English |
| Published: |
Faculdade de Medicina / USP
2017
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| Subjects: | |
| Online Access: |
http://repositorio.unb.br/handle/10482/29416 https://dx.doi.org/10.6061/clinics/2014(09)08 |
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| Summary: |
OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus. |
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