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Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis

The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and o...

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Main Authors: Colombo, N. B. R., Rangel, M. P., Silva, Vanessa Martins da, Hage, Marcia, Gelain, Daniel Pens, Barbeiro, Denise Frediani, Grisolia, Cesar Koppe, Parra, Edwin Roger Parra, Capelozzi, Vera Luiza
Format: Artigo
Language: English
Published: Associação Brasileira de Divulgação Científica 2017
Subjects:
Pequi
Stress oxidativo
Pulmões - câncer
Biologia molecular
Online Access: http://repositorio.unb.br/handle/10482/29582
http://dx.doi.org/10.1590/1414-431X20154467
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spelling ir-10482-295822019-10-14T11:57:51Z Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis Colombo, N. B. R. Rangel, M. P. Silva, Vanessa Martins da Hage, Marcia Gelain, Daniel Pens Barbeiro, Denise Frediani Grisolia, Cesar Koppe Parra, Edwin Roger Parra Capelozzi, Vera Luiza Pequi Stress oxidativo Pulmões - câncer Biologia molecular The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress. 2017-12-07T05:11:46Z 2017-12-07T05:11:46Z 2015-09 Artigo COLOMBO, N. B. R. et al. Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 48, n. 9, p. 852-862, set. 2015. DOI: http://dx.doi.org/10.1590/1414-431x20154467. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900852&lng=en&nrm=iso>. Acesso em: 14 out. 2019. Epub July 21, 2015. http://repositorio.unb.br/handle/10482/29582 http://dx.doi.org/10.1590/1414-431X20154467 en Acesso Aberto Brazilian Journal of Medical and Biological Research - (CC BY) - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900852&lng=en&nrm=iso. Acesso em: 14 out. 2019. application/pdf Associação Brasileira de Divulgação Científica
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language English
topic Pequi
Stress oxidativo
Pulmões - câncer
Biologia molecular
spellingShingle Pequi
Stress oxidativo
Pulmões - câncer
Biologia molecular
Colombo, N. B. R.
Rangel, M. P.
Silva, Vanessa Martins da
Hage, Marcia
Gelain, Daniel Pens
Barbeiro, Denise Frediani
Grisolia, Cesar Koppe
Parra, Edwin Roger Parra
Capelozzi, Vera Luiza
Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
description The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
format Artigo
author Colombo, N. B. R.
Rangel, M. P.
Silva, Vanessa Martins da
Hage, Marcia
Gelain, Daniel Pens
Barbeiro, Denise Frediani
Grisolia, Cesar Koppe
Parra, Edwin Roger Parra
Capelozzi, Vera Luiza
author_sort Colombo, N. B. R.
title Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
title_short Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
title_full Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
title_fullStr Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
title_full_unstemmed Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
title_sort caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
publisher Associação Brasileira de Divulgação Científica
publishDate 2017
url http://repositorio.unb.br/handle/10482/29582
http://dx.doi.org/10.1590/1414-431X20154467
_version_ 1648649415386202112
score 13.657419

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