Staff View: Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction

Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction

Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from da...

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Main Authors:	Alecrim, Hugo Muscelli, Duarte, Sérgio Andurte Carvalho, Amaral, Maria Eduarda Bonavides, Diógenis, Filipe, Carneiro, Fabiana Pirani, Sousa, João Batista de
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2017
Subjects:	Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos
Online Access:	http://repositorio.unb.br/handle/10482/29648 http://dx.doi.org/10.1590/S0102-86502015001000010
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spelling	ir-10482-296482018-11-20T11:34:26Z Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats. 2017-12-07T05:12:00Z 2017-12-07T05:12:00Z 2015-01 Artigo ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010. http://repositorio.unb.br/handle/10482/29648 http://dx.doi.org/10.1590/S0102-86502015001000010 en Acesso Aberto Acta Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso. Acesso em: 17 abr. 2018. application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos
spellingShingle	Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
description	Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats.
format	Artigo
author	Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de
author_sort	Alecrim, Hugo Muscelli
title	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
title_short	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
title_full	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
title_fullStr	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
title_full_unstemmed	Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
title_sort	effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate	2017
url	http://repositorio.unb.br/handle/10482/29648 http://dx.doi.org/10.1590/S0102-86502015001000010
_version_	1641988065281966080
score	13.657419

Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction

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