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Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study

Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can...

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Main Authors: Miranda-Vilela, Ana Luisa, Ribeiro, Ieler Ferreira, Grisolia, Cesar Koppe
Format: Artigo
Language: English
Published: Sociedade Brasileira de Genética 2017
Subjects:
Suplementação
Óleos vegetais
Indicadores
Polimorfismo (Genética)
Online Access: http://repositorio.unb.br/handle/10482/30339
http://dx.doi.org/10.1590/1678-4685-gmb-2015-0299
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spelling ir-10482-303392018-12-11T11:10:30Z Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study Miranda-Vilela, Ana Luisa Ribeiro, Ieler Ferreira Grisolia, Cesar Koppe Suplementação Óleos vegetais Indicadores Polimorfismo (Genética) Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations. 2017-12-07T05:18:43Z 2017-12-07T05:18:43Z 2016-10 Artigo MIRANDA-VILELA, Ana Luisa; RIBEIRO, Ieler Ferreira; GRISOLIA, Cesar Koppe. Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study. Genetics and Molecular Biology, Ribeirão Preto, v. 39, n. 4, p. 554-566, out./dez. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400554&lng=en&nrm=iso>. Acesso em: 21 dez. 2017. Epub Oct 10, 2016. doi: http://dx.doi.org/10.1590/1678-4685-gmb-2015-0299. http://repositorio.unb.br/handle/10482/30339 http://dx.doi.org/10.1590/1678-4685-gmb-2015-0299 en Acesso Aberto Genetics and Molecular Biology - This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400554&lng=en&nrm=iso. Acesso em: 21 dez. 2017. application/pdf Sociedade Brasileira de Genética
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language English
topic Suplementação
Óleos vegetais
Indicadores
Polimorfismo (Genética)
spellingShingle Suplementação
Óleos vegetais
Indicadores
Polimorfismo (Genética)
Miranda-Vilela, Ana Luisa
Ribeiro, Ieler Ferreira
Grisolia, Cesar Koppe
Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
description Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations.
format Artigo
author Miranda-Vilela, Ana Luisa
Ribeiro, Ieler Ferreira
Grisolia, Cesar Koppe
author_sort Miranda-Vilela, Ana Luisa
title Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
title_short Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
title_full Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
title_fullStr Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
title_full_unstemmed Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil : a before-after study
title_sort association between interleukin 6 -174 g/c promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (caryocar brasiliense camb.) oil : a before-after study
publisher Sociedade Brasileira de Genética
publishDate 2017
url http://repositorio.unb.br/handle/10482/30339
http://dx.doi.org/10.1590/1678-4685-gmb-2015-0299
_version_ 1641987975842627584
score 13.657419

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