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Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distin...

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Main Authors:	Vilela, Ana Luísa Miranda, Akimoto, Arthur Kenji, Alves, Penha Cristina Zaidan, Hiragi, Cássia de Oliveira, Penalva, Guilherme C., Oliveira, Silviene F., Grisolia, Cesar Koppe, Guimarães, Maria de Nazaré Klautau
Format:	Artigo
Language:	Inglês
Published:	Sociedade Brasileira de Genética 2018
Subjects:	Etnicidade - Brasil Proteínas Polimorfismo (Genética)
Online Access:	http://repositorio.unb.br/handle/10482/33142 http://dx.doi.org/10.1590/S1415-47572009005000051
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spelling	ir-10482-331422018-12-07T11:40:02Z Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities Vilela, Ana Luísa Miranda Akimoto, Arthur Kenji Alves, Penha Cristina Zaidan Hiragi, Cássia de Oliveira Penalva, Guilherme C. Oliveira, Silviene F. Grisolia, Cesar Koppe Guimarães, Maria de Nazaré Klautau Etnicidade - Brasil Proteínas Polimorfismo (Genética) Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp1 and Hp2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp1 allele has two subtypes, Hp1F and Hp1S, that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp1F/Hp1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp1F allele. However, despite the large variation in Hp1F frequencies, results of FST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp 1F and Hp1S frequencies among non-Amerindian Brazilians. 2018-12-07T11:39:35Z 2018-12-07T11:39:35Z 2009-06 Artigo MIRANDA-VILELA, Ana L. et al. Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities. Genetics and Molecular Biology, São Paulo, v. 32, n. 3, p. 456-461, jun. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300005&lng=en&nrm=iso>. Acesso em 25 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572009005000051. http://repositorio.unb.br/handle/10482/33142 http://dx.doi.org/10.1590/S1415-47572009005000051 Inglês Acesso Aberto Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300005&lng=en&nrm=iso. Acesso em: 25 out. 2017. application/pdf Sociedade Brasileira de Genética
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Etnicidade - Brasil Proteínas Polimorfismo (Genética)
spellingShingle	Etnicidade - Brasil Proteínas Polimorfismo (Genética) Vilela, Ana Luísa Miranda Akimoto, Arthur Kenji Alves, Penha Cristina Zaidan Hiragi, Cássia de Oliveira Penalva, Guilherme C. Oliveira, Silviene F. Grisolia, Cesar Koppe Guimarães, Maria de Nazaré Klautau Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
description	Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp1 and Hp2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp1 allele has two subtypes, Hp1F and Hp1S, that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp1F/Hp1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp1F allele. However, despite the large variation in Hp1F frequencies, results of FST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp 1F and Hp1S frequencies among non-Amerindian Brazilians.
format	Artigo
author	Vilela, Ana Luísa Miranda Akimoto, Arthur Kenji Alves, Penha Cristina Zaidan Hiragi, Cássia de Oliveira Penalva, Guilherme C. Oliveira, Silviene F. Grisolia, Cesar Koppe Guimarães, Maria de Nazaré Klautau
author_sort	Vilela, Ana Luísa Miranda
title	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
title_short	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
title_full	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
title_fullStr	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
title_full_unstemmed	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
title_sort	haptoglobin gene subtypes in three brazilian population groups of different ethnicities
publisher	Sociedade Brasileira de Genética
publishDate	2018
url	http://repositorio.unb.br/handle/10482/33142 http://dx.doi.org/10.1590/S1415-47572009005000051
_version_	1641988164919754752
score	13.657419

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

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