Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles : assessment of biocompatibility and potential applications
Nanoparticles’ unique features have been highly explored in cellular therapies. However, nanoparticles can be cytotoxic. The cytotoxicity can be overcome by coating the nanoparticles with an appropriated surface modification. Nanoparticle coating influences biocompatibility between nanoparticles and...
| Main Authors: | Silva, Luisa H. A., Silva, Jaqueline R. da, Ferreira, Guilherme A., Silva, Renata C., Lima, Emilia Celma de Oliveira, Azevedo, Ricardo Bentes de, Oliveira, Daniela M. |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2018
|
| Subjects: | |
| Online Access: |
http://repositorio.unb.br/handle/10482/33206 https://doi.org/10.1186/s12951-016-0213-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: |
Nanoparticles’ unique features have been highly explored in cellular therapies. However, nanoparticles can be cytotoxic. The cytotoxicity can be overcome by coating the nanoparticles with an appropriated surface modification. Nanoparticle coating influences biocompatibility between nanoparticles and cells and may affect some cell properties. Here, we evaluated the biocompatibility of gold and maghemite nanoparticles functionalized with 2,3-dimercaptosuccinic acid (DMSA), Au-DMSA and γ-Fe2O3-DMSA respectively, with human mesenchymal stem cells. Also, we tested these nanoparticles as tracers for mesenchymal stem cells in vivo tracking by computed tomography and as agents for mesenchymal stem cells magnetic targeting. |
|---|