Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surfacefunctionalization
The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small A...
| Main Authors: | Félix, L. León, Sanz, B., Sebastián, V., Torres, T. E., Sousa, Marcelo Henrique, Huamaní Coaquira, José Antonio, Ibarra, M. R., Goya, G. F. |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature
2019
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| Subjects: | |
| Online Access: |
https://repositorio.unb.br/handle/10482/35850 https://doi.org/10.1038/s41598-019-40769-2 https://orcid.org/0000-0002-6116-9331 https://orcid.org/0000-0003-1210-8329 https://orcid.org/0000-0003-1558-9279 |
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| Summary: |
The integration of noble metal and magnetic nanoparticles with controlled structures that can couple
various specific effects to the different nanocomposite in multifunctional nanosystems have been
found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au
nanoparticles of sizes <d> = 3.9 ± 0.2 nm attached to Fe3O4 nanoparticle cores (<d> = 49.2 ± 3.5 nm)
in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated
PEI-Fe3O4 (Au@PEI-Fe3O4) nanoparticles are able to retain bulk magnetic moment MS = 82–84 Am2/
kgFe3O4, with the Verwey transition observed at TV = 98 K. In addition, the in vitro cytotoxicity analysis of
the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 μg/mL
in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an
ac magnetic field (H0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of
SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe3O4 and Au@PEI-Fe3O4 NPs, respectively. These similar
intracellular SPA values imply that functionalization of the magnetic particles with Au did not change
the heating efficiency, providing at the same time a more flexible platform for multifunctional
functionalization. |
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