Staff View: Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults

Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults

This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participant...

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Main Authors:	Camargos, Einstein Francisco de, Goncalves, Isabela D., Bretones, Luiza Alvarenga Lima, Machado, Marcela F. M., Morais Júnior, Gilberto Santos, Brito, Artur Felipe Siqueira de, Henriques, Adriane Dallanora, Morais, Clayton Franco, Nóbrega, Otávio de Tolêdo
Format:	Artigo
Language:	Inglês
Published:	e-Century Publishing Corporation 2020
Subjects:	Apolipoproteína Genotipagem Sono Idosos Cognição - idosos
Online Access:	https://repositorio.unb.br/handle/10482/37258
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spelling	ir-10482-372582020-03-31T15:56:44Z Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults Camargos, Einstein Francisco de Goncalves, Isabela D. Bretones, Luiza Alvarenga Lima Machado, Marcela F. M. Morais Júnior, Gilberto Santos Brito, Artur Felipe Siqueira de Henriques, Adriane Dallanora Morais, Clayton Franco Nóbrega, Otávio de Tolêdo Apolipoproteína Genotipagem Sono Idosos Cognição - idosos This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders. Genotyping of classic polymorphic sites for the ApoE (rs429358 and rs7412) and the ACE (rs4646994) genes used peripheral DNA. A total of 63% of the subjects reported poor quality of sleep assessed by the PSQI whereas 54 (33%) reported daytime sleepiness through the Epworth scale. A significant correlation was observed between APOE and PSQI, with a greater frequency of the poor nighttime sleep quality phenotype among ε2 carriers, whereas no correlation was found among any of the sleep scores and the ACE genotypes. Thus, we suggest a correlation between APOE alleles and scale-assessed sleep quality scores in older adults, with no implications for ACE alleles, in a context devoid of cognitive impairment. 2020-03-31T15:56:44Z 2020-03-31T15:56:44Z 2019 Artigo CAMARGOS, Einstein F. et al. Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults. International Journal of Molecular Epidemiology and Genetics, Madison, v. 10, n. 4, p. 59-66, 2019. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737399/. Acesso em: 30 mar. 2020. https://repositorio.unb.br/handle/10482/37258 Inglês Acesso Aberto International Journal of Molecular Epidemiology and Genetics - Copyright Policy - Once the paper is published, the copyright will be released by the publisher under the “Creative Commons Attribution Noncommercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited. Fonte: http://ijmeg.org/ForAuthors.html. Acesso em: 30 mar. 2020. application/pdf e-Century Publishing Corporation
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Apolipoproteína Genotipagem Sono Idosos Cognição - idosos
spellingShingle	Apolipoproteína Genotipagem Sono Idosos Cognição - idosos Camargos, Einstein Francisco de Goncalves, Isabela D. Bretones, Luiza Alvarenga Lima Machado, Marcela F. M. Morais Júnior, Gilberto Santos Brito, Artur Felipe Siqueira de Henriques, Adriane Dallanora Morais, Clayton Franco Nóbrega, Otávio de Tolêdo Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
description	This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders. Genotyping of classic polymorphic sites for the ApoE (rs429358 and rs7412) and the ACE (rs4646994) genes used peripheral DNA. A total of 63% of the subjects reported poor quality of sleep assessed by the PSQI whereas 54 (33%) reported daytime sleepiness through the Epworth scale. A significant correlation was observed between APOE and PSQI, with a greater frequency of the poor nighttime sleep quality phenotype among ε2 carriers, whereas no correlation was found among any of the sleep scores and the ACE genotypes. Thus, we suggest a correlation between APOE alleles and scale-assessed sleep quality scores in older adults, with no implications for ACE alleles, in a context devoid of cognitive impairment.
format	Artigo
author	Camargos, Einstein Francisco de Goncalves, Isabela D. Bretones, Luiza Alvarenga Lima Machado, Marcela F. M. Morais Júnior, Gilberto Santos Brito, Artur Felipe Siqueira de Henriques, Adriane Dallanora Morais, Clayton Franco Nóbrega, Otávio de Tolêdo
author_sort	Camargos, Einstein Francisco de
title	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
title_short	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
title_full	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
title_fullStr	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
title_full_unstemmed	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults
title_sort	evidence for a contribution of the apoe (but not the ace) gene to the sleep profile of non-demented elderly adults
publisher	e-Century Publishing Corporation
publishDate	2020
url	https://repositorio.unb.br/handle/10482/37258
_version_	1672205923243786240
score	13.657419

Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults

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