Staff View: The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases

The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases

Nanostructures have been proposed as drug delivery systems in the treatment of hair follicle-related conditions because of their well-reported tendency to accumulate into the hair follicle shafts extending drug release. However, little is known about colloids behavior under diseased conditions as ac...

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Main Authors:	Tolentino, Seila, Pereira, Maira N., Sousa, Mikaella C. de, Cunha Filho, Marcílio Sérgio Soares da, Gelfuso, Guilherme Martins, Gratieri, Taís
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2020
Subjects:	Fosfato de clindamicina Doença folicular Folículo capilar Nanopartículas Pele
Online Access:	https://repositorio.unb.br/handle/10482/39538
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spelling	ir-10482-395382020-10-13T17:19:47Z The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases Tolentino, Seila Pereira, Maira N. Sousa, Mikaella C. de Cunha Filho, Marcílio Sérgio Soares da Gelfuso, Guilherme Martins Gratieri, Taís Fosfato de clindamicina Doença folicular Folículo capilar Nanopartículas Pele Nanostructures have been proposed as drug delivery systems in the treatment of hair follicle-related conditions because of their well-reported tendency to accumulate into the hair follicle shafts extending drug release. However, little is known about colloids behavior under diseased conditions as acne vulgaris, folliculitis, hidradenitis suppurativa, or capillary keratosis, in which there is an excess of sebum secretion that clogs the hair follicles. Here, we evaluated the influence of the sebaceous content on the performance of nanosystems by using an in vitro sebaceous skin model, in which the skin was massaged with a mixture of mutton tallow and vegetable oil in a 1:1 (w/w) preceding the permeation experiments. A nanostructured lipid carrier containing clindamycin phosphate (~90% of encapsulation efficiency) was used as a formulation model. Nanoparticles presented a mean diameter of 391.9 ± 8.6 nm, PDI of 0.16 ± 0.05, and positive zeta potential (+18.5 ± 1.5 mV). Stability studies confirmed nanoparticles were stable throughout all experiments, and drug release studies confirmed the controlled release profile. The results indicated the nanosystem performance was superior to the free drug in targeting the hair follicle in conventional skin permeation experiments, but no advantages of the colloidal system were observed when using the sebaceous skin model. Hence, the sebaceous content hampered nanoparticles deposition into the hair follicle shafts. In conclusion, the physiological skin condition must be considered when designing targeted drug delivery systems. The novel sebaceous skin model proposed in this paper can be used to evaluate, in a more realistic condition, the performance of the nanostructured systems intended for topical drug delivery in conditions of excess sebaceous secretion. 2020-10-13T17:19:18Z 2020-10-13T17:19:18Z 2020 Artigo TOLENTINO, Seila et al. The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases. Journal of Drug Delivery Science and Technology, v. 59, 101895, 2020. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1773224720311849. https://repositorio.unb.br/handle/10482/39538 Inglês https://www.sciencedirect.com/science/article/abs/pii/S1773224720311849 Acesso Restrito Elsevier
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Fosfato de clindamicina Doença folicular Folículo capilar Nanopartículas Pele
spellingShingle	Fosfato de clindamicina Doença folicular Folículo capilar Nanopartículas Pele Tolentino, Seila Pereira, Maira N. Sousa, Mikaella C. de Cunha Filho, Marcílio Sérgio Soares da Gelfuso, Guilherme Martins Gratieri, Taís The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
description	Nanostructures have been proposed as drug delivery systems in the treatment of hair follicle-related conditions because of their well-reported tendency to accumulate into the hair follicle shafts extending drug release. However, little is known about colloids behavior under diseased conditions as acne vulgaris, folliculitis, hidradenitis suppurativa, or capillary keratosis, in which there is an excess of sebum secretion that clogs the hair follicles. Here, we evaluated the influence of the sebaceous content on the performance of nanosystems by using an in vitro sebaceous skin model, in which the skin was massaged with a mixture of mutton tallow and vegetable oil in a 1:1 (w/w) preceding the permeation experiments. A nanostructured lipid carrier containing clindamycin phosphate (~90% of encapsulation efficiency) was used as a formulation model. Nanoparticles presented a mean diameter of 391.9 ± 8.6 nm, PDI of 0.16 ± 0.05, and positive zeta potential (+18.5 ± 1.5 mV). Stability studies confirmed nanoparticles were stable throughout all experiments, and drug release studies confirmed the controlled release profile. The results indicated the nanosystem performance was superior to the free drug in targeting the hair follicle in conventional skin permeation experiments, but no advantages of the colloidal system were observed when using the sebaceous skin model. Hence, the sebaceous content hampered nanoparticles deposition into the hair follicle shafts. In conclusion, the physiological skin condition must be considered when designing targeted drug delivery systems. The novel sebaceous skin model proposed in this paper can be used to evaluate, in a more realistic condition, the performance of the nanostructured systems intended for topical drug delivery in conditions of excess sebaceous secretion.
format	Artigo
author	Tolentino, Seila Pereira, Maira N. Sousa, Mikaella C. de Cunha Filho, Marcílio Sérgio Soares da Gelfuso, Guilherme Martins Gratieri, Taís
author_sort	Tolentino, Seila
title	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
title_short	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
title_full	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
title_fullStr	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
title_full_unstemmed	The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
title_sort	influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases
publisher	Elsevier
publishDate	2020
url	https://repositorio.unb.br/handle/10482/39538
_version_	1680624771407020032
score	13.657419

The influence of sebaceous content on the performance of nanosystems designed for the treatment of follicular diseases

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