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Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment

COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investi...

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Main Authors: Araujo, Felipe Saldanha de, Melgaço Garcez, Emãnuella, Carvalho, Amandda Évelin Silva, Carvalho, Juliana Lott
Format: Artigo
Language: Inglês
Published: Frontiers 2020
Subjects:
Covid-19
Células-tronco mesenquimais
Terapia com células-tronco
SARS-CoV-2
Ensaios clínicos
Online Access: https://repositorio.unb.br/handle/10482/39544
https://doi.org/10.3389/fimmu.2020.01563
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spelling ir-10482-395442021-10-15T12:09:21Z Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment Araujo, Felipe Saldanha de Melgaço Garcez, Emãnuella Carvalho, Amandda Évelin Silva Carvalho, Juliana Lott Covid-19 Células-tronco mesenquimais Terapia com células-tronco SARS-CoV-2 Ensaios clínicos COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underlying the application of stem cells to manage COVID-19, and also a comprehensive compendium of the 69 clinical trials underway worldwide aiming to investigate the application of stem cells to treat COVID-19. Even though data are still scarce, it is already possible to observe the protagonism of China in testing mesenchymal stem cells (MSCs) for COVID-19. Furthermore, it is possible to determine that current efforts focus on the use of multiple infusions of high numbers of stem cells and derived products, as well as to acknowledge the positive results obtained by independent groups who publicized the therapeutic benefits provided by such therapies in 51 COVID-19 patients. In such a rapid-paced field, up-to-date systematic studies and meta-analysis will aid the scientific community to separate hype from hope and offer an unbiased position to the society and governments. 2020-10-14T14:15:14Z 2020-10-14T14:15:14Z 2020-07-03 Artigo SALDANHA-ARAUJO, Felipe et al. Mesenchymal stem cells: a new piece in the puzzle of COVID-19 treatment. Frontiers in Immunology, v. 11, 1563, 2020. DOI: https://doi.org/10.3389/fimmu.2020.01563. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01563/full. Acesso em: 14 out. 2020. https://repositorio.unb.br/handle/10482/39544 https://doi.org/10.3389/fimmu.2020.01563 Inglês https://repositorio.unb.br/handle/10482/42137 Acesso Aberto Copyright © 2020 Saldanha-Araujo, Melgaço Garcez, Silva-Carvalho and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf Frontiers
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Covid-19
Células-tronco mesenquimais
Terapia com células-tronco
SARS-CoV-2
Ensaios clínicos
spellingShingle Covid-19
Células-tronco mesenquimais
Terapia com células-tronco
SARS-CoV-2
Ensaios clínicos
Araujo, Felipe Saldanha de
Melgaço Garcez, Emãnuella
Carvalho, Amandda Évelin Silva
Carvalho, Juliana Lott
Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
description COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underlying the application of stem cells to manage COVID-19, and also a comprehensive compendium of the 69 clinical trials underway worldwide aiming to investigate the application of stem cells to treat COVID-19. Even though data are still scarce, it is already possible to observe the protagonism of China in testing mesenchymal stem cells (MSCs) for COVID-19. Furthermore, it is possible to determine that current efforts focus on the use of multiple infusions of high numbers of stem cells and derived products, as well as to acknowledge the positive results obtained by independent groups who publicized the therapeutic benefits provided by such therapies in 51 COVID-19 patients. In such a rapid-paced field, up-to-date systematic studies and meta-analysis will aid the scientific community to separate hype from hope and offer an unbiased position to the society and governments.
format Artigo
author Araujo, Felipe Saldanha de
Melgaço Garcez, Emãnuella
Carvalho, Amandda Évelin Silva
Carvalho, Juliana Lott
author_sort Araujo, Felipe Saldanha de
title Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
title_short Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
title_full Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
title_fullStr Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
title_full_unstemmed Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
title_sort mesenchymal stem cells : a new piece in the puzzle of covid-19 treatment
publisher Frontiers
publishDate 2020
url https://repositorio.unb.br/handle/10482/39544
https://doi.org/10.3389/fimmu.2020.01563
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score 13.657419

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