Association of vitamin D with the TaqI polymorphism of the VDR gene in older women attending the basic health unit of the Federal District, DF (Brazil)
Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chanc...
| Main Authors: | Freitas, Renata de Souza, Fratelli, Caroline Ferreira, Silva, Calliandra Maria de Souza, Lima, Luciano Ramos de, Stival, Marina Morato, Silva, Izabel Cristina Rodrigues da, Funghetto, Silvana Schwerz |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Hindawi
2020
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| Subjects: | |
| Online Access: |
https://repositorio.unb.br/handle/10482/39717 https://doi.org/10.1155/2020/7145193 https://orcid.org/0000-0003-3563-6415 https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-2709-6335 https://orcid.org/0000-0001-6830-4914 https://orcid.org/0000-0002-6836-3583 https://orcid.org/0000-0002-9332-9029 |
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| Summary: |
Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chances of developing noncommunicable chronic diseases. The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. The study was a descriptive, case-control, quantitative, and cross-sectional type and was conducted in two basic health units in the administrative region of Ceilândia, Federal District, DF, Brazil, with women aged 60 years or older. Anthropometric, biochemical, and genetic parameters (VDR TaqI polymorphism) were evaluated. The adopted significance level was 5%, and statistical analyses were performed using the SPSS version 20.0 program. The study consisted of 128 participants. The most prevalent age was from 60 to 65 years (N = 53; 41.4%). 66 elderly (51.6%) were part of the case group (hypovitaminosis D), while 62 were in the control group. In the case group, 30.2% had grade I obesity, 77.3% were hypertensive, and 51.5% were diabetic. The TT genotype was present in 47% of the case group and 54.8% in the control group (). There was no association between serum vitamin D levels and the VDR gene variant TaqI polymorphism in an elderly Brazilian population. |
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