Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)
The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions t...
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ir-10482-398752021-01-11T18:41:52Z Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) McCullough, Peter A. Alexander, Paul E. Armstrong, Robin Arvinte, Cristian Bain, Alan F. Bartlett, Richard P. Berkowitz, Robert L. Berry, Andrew C. Borody, Thomas J. Brewer, Joseph H. Brufsky, Adam M. Clarke, Teryn Derwand, Roland Eck, Alieta Eck, John Eisner, Richard A. Fareed, George C. Farella, Angelina Fonseca, Silvia N. S. Geyer Jr., Charles E. Gonnering, Russell S. Graves, Karladine E. Gross, Kenneth B. V. Hazan, Sabine Held, Kristin S. Hight, H. Thomas Immanuel, Stella Jacobs, Michael M. Ladapo, Joseph A. Lee, Lionel H. Littell, John Lozano, Ivette Mangat, Harpal S. McKinnon, John E. Merritt, Lee D. Orient, Jane M. Oskoui, Ramin Pompan, Donald C. Procter, Brian C. Prodromos, Chad Rajter, Juliana Cepelowicz Rajter, Jean-Jacques Ram, C. Venkata S. Rios, Salete da Silva Risch, Harvey A. Robb, Michael J. A. Rutherford, Molly Scholz, Martin Singleton, Marilyn M. Tumlin, James A. Tyson, Brian M. Urso, Richard G. Victory, Kelly Vliet, Elizabeth Lee Wax, Craig M. Wolkoff, Alexandre G. Wooll, Vicki Zelenko, Vladimir SARS-CoV-2 Covid-19 Hospitalização Mortalidade Tratamento Medicamentos The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. 2021-01-11T18:41:52Z 2021-01-11T18:41:52Z 2020-12-30 Artigo MCCULLOUGH, Peter A. et al. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine, v. 21, n. 4, p. 517-530, 2020. DOI: 10.31083/j.rcm.2020.04.264. Disponível em: https://rcm.imrpress.com/article/2020/2153-8174/RCM2020264.shtml. Acesso em: 11 jan. 2021. https://repositorio.unb.br/handle/10482/39875 10.31083/j.rcm.2020.04.264 https://orcid.org/0000-0002-0997-6355 https://orcid.org/0000-0001-8425-438X https://orcid.org/0000-0001-8952-6559 https://orcid.org/0000-0001-8080-7960 https://orcid.org/0000-0002-2379-5702 https://orcid.org/0000-0002-5228-7512 https://orcid.org/0000-0003-1846-6354 https://orcid.org/0000-0003-3916-4021 https://orcid.org/0000-0003-4378-3458 https://orcid.org/0000-0003-3520-281X https://orcid.org/0000-0003-1162-6263 https://orcid.org/0000-0001-5337-3941 https://orcid.org/0000-0002-3019-4139 https://orcid.org/0000-0002-2373-2576 https://orcid.org/0000-0001-8681-8214 https://orcid.org/0000-0003-4347-8621 Inglês Acesso Aberto This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). application/pdf IMR Press |
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REPOSITORIO UNB |
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REPOSITORIO UNB |
| language |
Inglês |
| topic |
SARS-CoV-2 Covid-19 Hospitalização Mortalidade Tratamento Medicamentos |
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SARS-CoV-2 Covid-19 Hospitalização Mortalidade Tratamento Medicamentos McCullough, Peter A. Alexander, Paul E. Armstrong, Robin Arvinte, Cristian Bain, Alan F. Bartlett, Richard P. Berkowitz, Robert L. Berry, Andrew C. Borody, Thomas J. Brewer, Joseph H. Brufsky, Adam M. Clarke, Teryn Derwand, Roland Eck, Alieta Eck, John Eisner, Richard A. Fareed, George C. Farella, Angelina Fonseca, Silvia N. S. Geyer Jr., Charles E. Gonnering, Russell S. Graves, Karladine E. Gross, Kenneth B. V. Hazan, Sabine Held, Kristin S. Hight, H. Thomas Immanuel, Stella Jacobs, Michael M. Ladapo, Joseph A. Lee, Lionel H. Littell, John Lozano, Ivette Mangat, Harpal S. McKinnon, John E. Merritt, Lee D. Orient, Jane M. Oskoui, Ramin Pompan, Donald C. Procter, Brian C. Prodromos, Chad Rajter, Juliana Cepelowicz Rajter, Jean-Jacques Ram, C. Venkata S. Rios, Salete da Silva Risch, Harvey A. Robb, Michael J. A. Rutherford, Molly Scholz, Martin Singleton, Marilyn M. Tumlin, James A. Tyson, Brian M. Urso, Richard G. Victory, Kelly Vliet, Elizabeth Lee Wax, Craig M. Wolkoff, Alexandre G. Wooll, Vicki Zelenko, Vladimir Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| description |
The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and
death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated
organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating
illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without
early treatment can succumb to delayed in-hospital
care and death. Prompt early initiation of sequenced multidrug
therapy (SMDT) is a widely and currently available
solution to stem the tide of hospitalizations and death. A
multipronged therapeutic approach includes 1) adjuvant
nutraceuticals, 2) combination intracellular anti-infective
therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet
agents/anticoagulants, 5) supportive care including supplemental
oxygen, monitoring, and telemedicine. Randomized
trials of individual, novel oral therapies have not
delivered tools for physicians to combat the pandemic in
practice. No single therapeutic option thus far has been
entirely effective and therefore a combination is required
at this time. An urgent immediate pivot from single drug to
SMDT regimens should be employed as a critical strategy
to deal with the large numbers of acute COVID-19 patients
with the aim of reducing the intensity and duration
of symptoms and avoiding hospitalization and death. |
| format |
Artigo |
| author |
McCullough, Peter A. Alexander, Paul E. Armstrong, Robin Arvinte, Cristian Bain, Alan F. Bartlett, Richard P. Berkowitz, Robert L. Berry, Andrew C. Borody, Thomas J. Brewer, Joseph H. Brufsky, Adam M. Clarke, Teryn Derwand, Roland Eck, Alieta Eck, John Eisner, Richard A. Fareed, George C. Farella, Angelina Fonseca, Silvia N. S. Geyer Jr., Charles E. Gonnering, Russell S. Graves, Karladine E. Gross, Kenneth B. V. Hazan, Sabine Held, Kristin S. Hight, H. Thomas Immanuel, Stella Jacobs, Michael M. Ladapo, Joseph A. Lee, Lionel H. Littell, John Lozano, Ivette Mangat, Harpal S. McKinnon, John E. Merritt, Lee D. Orient, Jane M. Oskoui, Ramin Pompan, Donald C. Procter, Brian C. Prodromos, Chad Rajter, Juliana Cepelowicz Rajter, Jean-Jacques Ram, C. Venkata S. Rios, Salete da Silva Risch, Harvey A. Robb, Michael J. A. Rutherford, Molly Scholz, Martin Singleton, Marilyn M. Tumlin, James A. Tyson, Brian M. Urso, Richard G. Victory, Kelly Vliet, Elizabeth Lee Wax, Craig M. Wolkoff, Alexandre G. Wooll, Vicki Zelenko, Vladimir |
| author_sort |
McCullough, Peter A. |
| title |
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| title_short |
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| title_full |
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| title_fullStr |
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| title_full_unstemmed |
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
| title_sort |
multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk sars-cov-2 infection (covid-19) |
| publisher |
IMR Press |
| publishDate |
2021 |
| url |
https://repositorio.unb.br/handle/10482/39875 https://orcid.org/0000-0002-0997-6355 https://orcid.org/0000-0001-8425-438X https://orcid.org/0000-0001-8952-6559 https://orcid.org/0000-0001-8080-7960 https://orcid.org/0000-0002-2379-5702 https://orcid.org/0000-0002-5228-7512 https://orcid.org/0000-0003-1846-6354 https://orcid.org/0000-0003-3916-4021 https://orcid.org/0000-0003-4378-3458 https://orcid.org/0000-0003-3520-281X https://orcid.org/0000-0003-1162-6263 https://orcid.org/0000-0001-5337-3941 https://orcid.org/0000-0002-3019-4139 https://orcid.org/0000-0002-2373-2576 https://orcid.org/0000-0001-8681-8214 https://orcid.org/0000-0003-4347-8621 |
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13.657419 |