Cover Image

Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19

Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the m...

Full description

Main Authors: Loyola, Mariana Braccialli de, Reis, Thaís Tereza Aguiar dos, Oliveira, Guilherme Xavier Lyra Malcher de, Palmeira, Julys da Fonseca, Argañaraz, Gustavo Adolfo, Argañaraz, Enrique Roberto
Format: Artigo
Language: Inglês
Published: Wiley 2021
Subjects:
A1AT
ADAM17
Covid-19
SARS-CoV-2
TMPRSS2
Online Access: https://repositorio.unb.br/handle/10482/39924
https://doi.org/10.1002/rmv.2157
https://orcid.org/0000-0002-7816-764X
https://orcid.org/0000-0002-4359-7594
Tags: Add Tag
No Tags, Be the first to tag this record!
id ir-10482-39924
recordtype dspace
spelling ir-10482-399242021-04-28T16:08:59Z Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19 Loyola, Mariana Braccialli de Reis, Thaís Tereza Aguiar dos Oliveira, Guilherme Xavier Lyra Malcher de Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto A1AT ADAM17 Covid-19 SARS-CoV-2 TMPRSS2 Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL‐8, TNF‐α, and neutrophil elastase (NE). TMPRSS2 is essential for SARS‐CoV‐2‐S protein priming and viral infection. ADAM17 mediates ACE2, IL‐6R, and TNF‐α shedding. ACE2 is the SARS‐CoV‐2 entry receptor and a key component for the balance of the renin‐angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid‐19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid‐19, opening new avenues for investigating effective treatments. 2021-01-18T13:39:23Z 2021-01-18T13:39:23Z 2020-08-26 Artigo LOYOLA, Mariana Braccialli de et al. Alpha‐1‐antitrypsin: a possible host protective factor against Covid‐19. Reviews in Medical Virology, e2157, 2020. DOI: https://doi.org/10.1002/rmv.2157. Disponível em: https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2157. https://repositorio.unb.br/handle/10482/39924 https://doi.org/10.1002/rmv.2157 https://orcid.org/0000-0002-7816-764X https://orcid.org/0000-0002-4359-7594 Inglês https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2157 Acesso Aberto Wiley
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic A1AT
ADAM17
Covid-19
SARS-CoV-2
TMPRSS2
spellingShingle A1AT
ADAM17
Covid-19
SARS-CoV-2
TMPRSS2
Loyola, Mariana Braccialli de
Reis, Thaís Tereza Aguiar dos
Oliveira, Guilherme Xavier Lyra Malcher de
Palmeira, Julys da Fonseca
Argañaraz, Gustavo Adolfo
Argañaraz, Enrique Roberto
Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
description Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL‐8, TNF‐α, and neutrophil elastase (NE). TMPRSS2 is essential for SARS‐CoV‐2‐S protein priming and viral infection. ADAM17 mediates ACE2, IL‐6R, and TNF‐α shedding. ACE2 is the SARS‐CoV‐2 entry receptor and a key component for the balance of the renin‐angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid‐19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid‐19, opening new avenues for investigating effective treatments.
format Artigo
author Loyola, Mariana Braccialli de
Reis, Thaís Tereza Aguiar dos
Oliveira, Guilherme Xavier Lyra Malcher de
Palmeira, Julys da Fonseca
Argañaraz, Gustavo Adolfo
Argañaraz, Enrique Roberto
author_sort Loyola, Mariana Braccialli de
title Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
title_short Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
title_full Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
title_fullStr Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
title_full_unstemmed Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
title_sort alpha‐1‐antitrypsin : a possible host protective factor against covid‐19
publisher Wiley
publishDate 2021
url https://repositorio.unb.br/handle/10482/39924
https://doi.org/10.1002/rmv.2157
https://orcid.org/0000-0002-7816-764X
https://orcid.org/0000-0002-4359-7594
_version_ 1710449496943493120
score 13.657419

Similar Items