Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage
Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acu...
| Main Authors: | Morais Júnior, Gilberto Santos, Kurizky, Patricia Shu, Cerqueira, Selma Regina Penha Silva, Barroso, Daniel Holanda, Schulte, Heidi Luise, Albuquerque, Cleandro Pires de, Gois, Eliana Teles de, Espindola, Laila Salmen, Santana, Jaime Martins de, Bastos, Izabela Marques Dourado, Araújo, Carla Nunes de, Mota, Licia Maria Henrique da, Nóbrega, Otávio de Tolêdo, Gomes, Ciro Martins |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Tropical Medicine and Hygiene
2021
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| Subjects: | |
| Online Access: |
https://repositorio.unb.br/handle/10482/40909 https://doi.org/10.4269/ajtmh.21-0034 |
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| Summary: |
Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state. |
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