Staff View: A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil

A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil

We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K....

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Main Authors:	Campos, Tatiana Amabile de, Gonçalves, Laura Fernandes, Magalhães, Kelly Grace, Martins, Vicente de Paulo, Pappas Júnior, Georgios Joannis, Peirano, Gisele, Pitout, Johann D. D., Gonçalves, Guilherme Bartolomeu, Furlan, João Pedro Rueda, Stehling, Eliana Guedes, Pitondo-Silva, André
Format:	Artigo
Language:	Inglês
Published:	Frontiers 2021
Subjects:	Klebsiella pneumoniae Virulência (Microbiologia) Resistência antimicrobiana
Online Access:	https://repositorio.unb.br/handle/10482/40952 https://doi.org/10.3389/fmed.2018.00265
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spelling	ir-10482-409522021-05-19T19:36:26Z A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil Campos, Tatiana Amabile de Gonçalves, Laura Fernandes Magalhães, Kelly Grace Martins, Vicente de Paulo Pappas Júnior, Georgios Joannis Peirano, Gisele Pitout, Johann D. D. Gonçalves, Guilherme Bartolomeu Furlan, João Pedro Rueda Stehling, Eliana Guedes Pitondo-Silva, André Klebsiella pneumoniae Virulência (Microbiologia) Resistência antimicrobiana We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients. 2021-05-19T19:36:26Z 2021-05-19T19:36:26Z 2018 Artigo CAMPOS, Tatiana Amabile de et al. A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil. Frontiers in Medicine, v. 5, 265, 2018. DOI: 10.3389/fmed.2018.00265. Disponível em: https://www.frontiersin.org/articles/10.3389/fmed.2018.00265/full. Acesso em: 14 maio 2021. https://repositorio.unb.br/handle/10482/40952 https://doi.org/10.3389/fmed.2018.00265 Inglês Acesso Aberto © 2018 de Campos, Gonçalves, Magalhães, de Paulo Martins, Pappas Júnior, Peirano, Pitout, Gonçalves, Furlan, Stehling and Pitondo-Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf Frontiers
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Klebsiella pneumoniae Virulência (Microbiologia) Resistência antimicrobiana
spellingShingle	Klebsiella pneumoniae Virulência (Microbiologia) Resistência antimicrobiana Campos, Tatiana Amabile de Gonçalves, Laura Fernandes Magalhães, Kelly Grace Martins, Vicente de Paulo Pappas Júnior, Georgios Joannis Peirano, Gisele Pitout, Johann D. D. Gonçalves, Guilherme Bartolomeu Furlan, João Pedro Rueda Stehling, Eliana Guedes Pitondo-Silva, André A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
description	We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients.
format	Artigo
author	Campos, Tatiana Amabile de Gonçalves, Laura Fernandes Magalhães, Kelly Grace Martins, Vicente de Paulo Pappas Júnior, Georgios Joannis Peirano, Gisele Pitout, Johann D. D. Gonçalves, Guilherme Bartolomeu Furlan, João Pedro Rueda Stehling, Eliana Guedes Pitondo-Silva, André
author_sort	Campos, Tatiana Amabile de
title	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_short	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_full	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_fullStr	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_full_unstemmed	A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_sort	fatal bacteremia caused by hypermucousviscous kpc-2 producing extensively drug-resistant k64-st11 klebsiella pneumoniae in brazil
publisher	Frontiers
publishDate	2021
url	https://repositorio.unb.br/handle/10482/40952 https://doi.org/10.3389/fmed.2018.00265
_version_	1710449461018230784
score	13.657419

A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil

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