Lysophosphatidylcholine induces NLRP3 inflammasome-mediated foam cell formation and pyroptosis in human monocytes and endothelial cells
Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of proinflammatory activities and plays a key role in athero...
| Main Authors: | Corrêa, Rafael, Silva, Luís Felipe Fonseca, Ribeiro, Dalila Juliana Silva, Almeida, Raquel das Neves, Santos, Igor de Oliveira, Corrêa, Luís Henrique, Sant'Ana, Lívia Pimentel de, Assunção, Leonardo Santos, Bozza, Patricia Torres, Magalhães, Kelly Grace |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers
2021
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| Subjects: | |
| Online Access: |
https://repositorio.unb.br/handle/10482/40953 https://doi.org/10.3389/fimmu.2019.02927 |
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