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Biomarkers in colorectal cancer : the role of translational proteomics research

Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from t...

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Main Authors: Martins, Bruno Augusto Alves, Bulhões, Gabriel Fonseca de, Cavalcanti, Igor Norat, Martins, Mickaella Michelson, Oliveira, Paulo Gonçalves de, Martins, Aline Maria Araújo
Format: Artigo
Language: Inglês
Published: Frontiers 2021
Subjects:
Cólon (Anatomia) - câncer
Biomarcadores
Proteômica
Espectrometria de massa
Online Access: https://repositorio.unb.br/handle/10482/40954
https://doi.org/10.3389/fonc.2019.01284
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spelling ir-10482-409542021-05-19T19:47:28Z Biomarkers in colorectal cancer : the role of translational proteomics research Martins, Bruno Augusto Alves Bulhões, Gabriel Fonseca de Cavalcanti, Igor Norat Martins, Mickaella Michelson Oliveira, Paulo Gonçalves de Martins, Aline Maria Araújo Cólon (Anatomia) - câncer Biomarcadores Proteômica Espectrometria de massa Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from the prevention and early diagnosis to the determination of prognosis factors and treatment of metastatic disease, to establish a personalized approach. The genetic profile approach has been increasingly used in the decision-making process, especially in the choice of targeted therapies and in the prediction of drug response, but there are still few validated biomarkers of colorectal cancer for clinical practice. The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through proteomics studies according to biomarker function and clinical application. 2021-05-19T19:47:28Z 2021-05-19T19:47:28Z 2019 Artigo MARTINS, Bruno Augusto Alves et al. Biomarkers in colorectal cancer: the role of translational proteomics research. Frontiers in Oncology, v. 9, 1284, 2019. DOI: 10.3389/fonc.2019.01284. Disponível em: https://www.frontiersin.org/articles/10.3389/fonc.2019.01284/full. Acesso em: 14 maio 2021. https://repositorio.unb.br/handle/10482/40954 https://doi.org/10.3389/fonc.2019.01284 Inglês Acesso Aberto (CC BY) - Copyright © 2019 Alves Martins, de Bulhões, Cavalcanti, Martins, de Oliveira and Martins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf Frontiers
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Cólon (Anatomia) - câncer
Biomarcadores
Proteômica
Espectrometria de massa
spellingShingle Cólon (Anatomia) - câncer
Biomarcadores
Proteômica
Espectrometria de massa
Martins, Bruno Augusto Alves
Bulhões, Gabriel Fonseca de
Cavalcanti, Igor Norat
Martins, Mickaella Michelson
Oliveira, Paulo Gonçalves de
Martins, Aline Maria Araújo
Biomarkers in colorectal cancer : the role of translational proteomics research
description Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from the prevention and early diagnosis to the determination of prognosis factors and treatment of metastatic disease, to establish a personalized approach. The genetic profile approach has been increasingly used in the decision-making process, especially in the choice of targeted therapies and in the prediction of drug response, but there are still few validated biomarkers of colorectal cancer for clinical practice. The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through proteomics studies according to biomarker function and clinical application.
format Artigo
author Martins, Bruno Augusto Alves
Bulhões, Gabriel Fonseca de
Cavalcanti, Igor Norat
Martins, Mickaella Michelson
Oliveira, Paulo Gonçalves de
Martins, Aline Maria Araújo
author_sort Martins, Bruno Augusto Alves
title Biomarkers in colorectal cancer : the role of translational proteomics research
title_short Biomarkers in colorectal cancer : the role of translational proteomics research
title_full Biomarkers in colorectal cancer : the role of translational proteomics research
title_fullStr Biomarkers in colorectal cancer : the role of translational proteomics research
title_full_unstemmed Biomarkers in colorectal cancer : the role of translational proteomics research
title_sort biomarkers in colorectal cancer : the role of translational proteomics research
publisher Frontiers
publishDate 2021
url https://repositorio.unb.br/handle/10482/40954
https://doi.org/10.3389/fonc.2019.01284
_version_ 1705993345151533056
score 13.657419

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