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The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy

Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study w...

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Main Authors: Cerqueira, Adara Rodrigues Damasceno, Fratelli, Caroline Ferreira, Duarte, Ligia Canongia de Abreu Cardoso, Pereira, Alexandre Sampaio Rodrigues, Morais, Rafael Martins de, Sobrinho, Alaor Barra Sobrinho, Silva, Calliandra Maria de Souza, Silva, Izabel Cristina Rodrigues da, Oliveira, Jamila Reis de
Format: Artigo
Language: Inglês
Published: Sage 2021
Subjects:
Polimorfismo genético
Tireóide - câncer
Tireoidectomia
Óxido nítrico
Online Access: https://repositorio.unb.br/handle/10482/41510
https://doi.org/10.1177/1724600820961787
https://orcid.org/0000-0002-0511-9452
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spelling ir-10482-415102021-07-29T13:47:16Z The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy Cerqueira, Adara Rodrigues Damasceno Fratelli, Caroline Ferreira Duarte, Ligia Canongia de Abreu Cardoso Pereira, Alexandre Sampaio Rodrigues Morais, Rafael Martins de Sobrinho, Alaor Barra Sobrinho Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Oliveira, Jamila Reis de Polimorfismo genético Tireóide - câncer Tireoidectomia Óxido nítrico Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study was conducted with 31 papillary thyroid cancer patients of both genders who underwent thyroidectomy and treatment with sodium iodide radiopharmaceutical (131I) compared with 81 control patients. Through papillary thyroid cancer, the results were observed, compiled, and analyzed using SPSS version 25.0. The significance level of 5% was adopted. Genotypic frequencies of healthy subjects were in the Hardy-Weinberg equilibrium (P = 0.503). There was a significant genotypic difference between papillary thyroid cancer and healthy individuals (P <0.001). The BB genotype conferred a protective factor for papillary thyroid cancer (P <0.001, odds ratio (OR) 0.16; 95% confidence interval (CI) 0.06, 0.42), while the presence of the A allele appears to be a risk factor for papillary thyroid cancer (P <0.001, OR 3.54; 95% CI 1.86, 6.73). The intron 4 polymorphism of the NOS3 gene was associated with susceptibility to papillary thyroid cancer. Thus, future research into the effects of this polymorphism is essential. 2021-07-28T02:04:44Z 2021-07-28T02:04:44Z 2020 Artigo CERQUEIRA, Adara Rodrigues Damasceno. The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy. The International Journal of Biological Markers, v. 35, n. 4, p. 87-91, 2020. DOI: https://doi.org/10.1177/1724600820961787. Disponível em: https://journals.sagepub.com/doi/full/10.1177/1724600820961787. Acesso em: 26 jul. 2021. https://repositorio.unb.br/handle/10482/41510 https://doi.org/10.1177/1724600820961787 https://orcid.org/0000-0002-0511-9452 Inglês Acesso Aberto Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). application/pdf Sage
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Polimorfismo genético
Tireóide - câncer
Tireoidectomia
Óxido nítrico
spellingShingle Polimorfismo genético
Tireóide - câncer
Tireoidectomia
Óxido nítrico
Cerqueira, Adara Rodrigues Damasceno
Fratelli, Caroline Ferreira
Duarte, Ligia Canongia de Abreu Cardoso
Pereira, Alexandre Sampaio Rodrigues
Morais, Rafael Martins de
Sobrinho, Alaor Barra Sobrinho
Silva, Calliandra Maria de Souza
Silva, Izabel Cristina Rodrigues da
Oliveira, Jamila Reis de
The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
description Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study was conducted with 31 papillary thyroid cancer patients of both genders who underwent thyroidectomy and treatment with sodium iodide radiopharmaceutical (131I) compared with 81 control patients. Through papillary thyroid cancer, the results were observed, compiled, and analyzed using SPSS version 25.0. The significance level of 5% was adopted. Genotypic frequencies of healthy subjects were in the Hardy-Weinberg equilibrium (P = 0.503). There was a significant genotypic difference between papillary thyroid cancer and healthy individuals (P <0.001). The BB genotype conferred a protective factor for papillary thyroid cancer (P <0.001, odds ratio (OR) 0.16; 95% confidence interval (CI) 0.06, 0.42), while the presence of the A allele appears to be a risk factor for papillary thyroid cancer (P <0.001, OR 3.54; 95% CI 1.86, 6.73). The intron 4 polymorphism of the NOS3 gene was associated with susceptibility to papillary thyroid cancer. Thus, future research into the effects of this polymorphism is essential.
format Artigo
author Cerqueira, Adara Rodrigues Damasceno
Fratelli, Caroline Ferreira
Duarte, Ligia Canongia de Abreu Cardoso
Pereira, Alexandre Sampaio Rodrigues
Morais, Rafael Martins de
Sobrinho, Alaor Barra Sobrinho
Silva, Calliandra Maria de Souza
Silva, Izabel Cristina Rodrigues da
Oliveira, Jamila Reis de
author_sort Cerqueira, Adara Rodrigues Damasceno
title The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
title_short The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
title_full The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
title_fullStr The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
title_full_unstemmed The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
title_sort impact of nos3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
publisher Sage
publishDate 2021
url https://repositorio.unb.br/handle/10482/41510
https://doi.org/10.1177/1724600820961787
https://orcid.org/0000-0002-0511-9452
_version_ 1710449622966599680
score 13.657419

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