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Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys

The spontaneous object recognition (SOR) task is one of the most widely used behavioral protocols to assess visual memory in animals. However, only recently was it shown that nonhuman primates also perform well on this task. Here we further characterized this new monkey recognition memory test by as...

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Main Authors: Oliveira, André Wagner Carvalho de, Pacheco, Jéssica V. N., Costa, Clara de Sena, Aquino, Jéssica, Maior, Rafael Plakoudi Souto, Barros, Marilia
Format: Artigo
Language: Inglês
Published: Elsevier Inc. 2021
Subjects:
Sagui
Memória de reconhecimento
Escopolamina
MK-801
Donepezila
Online Access: https://repositorio.unb.br/handle/10482/42452
https://doi.org/10.1016/j.pbb.2021.173300
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spelling ir-10482-424522021-11-25T12:27:54Z Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys Oliveira, André Wagner Carvalho de Pacheco, Jéssica V. N. Costa, Clara de Sena Aquino, Jéssica Maior, Rafael Plakoudi Souto Barros, Marilia Sagui Memória de reconhecimento Escopolamina MK-801 Donepezila The spontaneous object recognition (SOR) task is one of the most widely used behavioral protocols to assess visual memory in animals. However, only recently was it shown that nonhuman primates also perform well on this task. Here we further characterized this new monkey recognition memory test by assessing the performance of adult marmosets after an acute systemic administration of two putative amnesic agents: the competitive muscarinic acetylcholine receptor antagonist scopolamine (SCP; 0.05 mg/kg) and the noncompetitive N-methyl-d-aspartate glutamate receptor antagonist MK-801 (0.015 mg/kg). We also determined whether the acetylcholinesterase inhibitor donepezil (DNP; 0.50 mg/kg), a clinically-used cognitive enhancer, reverses memory deficits caused by either drug. The subjects had an initial 10 min sample trial where two identical neutral objects could be explored. After a 6 h retention interval, recognition was based on an exploratory preference for a new rather than familiar object during a 10 min test trial. Both SCP and MK-801 impaired the marmosets' performance on the SOR task, as both objects were explored equivalently. Co-administration of 0.50 mg/kg of DNP reversed the SCP- but not the MK-801-induced memory deficit. These results indicate that cholinergic and glutamatergic pathways mediate object recognition memory in the monkey SOR task. 2021-11-25T12:07:11Z 2021-11-25T12:07:11Z 2021-10-16 Artigo OLIVEIRA, André W. C. et al. Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys. Pharmacology Biochemistry and Behavior, v. 21, 173300, dez. 2021. DOI: https://doi.org/10.1016/j.pbb.2021.173300. https://repositorio.unb.br/handle/10482/42452 https://doi.org/10.1016/j.pbb.2021.173300 Inglês https://www.sciencedirect.com/science/article/abs/pii/S0091305721001994#! Acesso Restrito Elsevier Inc.
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Sagui
Memória de reconhecimento
Escopolamina
MK-801
Donepezila
spellingShingle Sagui
Memória de reconhecimento
Escopolamina
MK-801
Donepezila
Oliveira, André Wagner Carvalho de
Pacheco, Jéssica V. N.
Costa, Clara de Sena
Aquino, Jéssica
Maior, Rafael Plakoudi Souto
Barros, Marilia
Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
description The spontaneous object recognition (SOR) task is one of the most widely used behavioral protocols to assess visual memory in animals. However, only recently was it shown that nonhuman primates also perform well on this task. Here we further characterized this new monkey recognition memory test by assessing the performance of adult marmosets after an acute systemic administration of two putative amnesic agents: the competitive muscarinic acetylcholine receptor antagonist scopolamine (SCP; 0.05 mg/kg) and the noncompetitive N-methyl-d-aspartate glutamate receptor antagonist MK-801 (0.015 mg/kg). We also determined whether the acetylcholinesterase inhibitor donepezil (DNP; 0.50 mg/kg), a clinically-used cognitive enhancer, reverses memory deficits caused by either drug. The subjects had an initial 10 min sample trial where two identical neutral objects could be explored. After a 6 h retention interval, recognition was based on an exploratory preference for a new rather than familiar object during a 10 min test trial. Both SCP and MK-801 impaired the marmosets' performance on the SOR task, as both objects were explored equivalently. Co-administration of 0.50 mg/kg of DNP reversed the SCP- but not the MK-801-induced memory deficit. These results indicate that cholinergic and glutamatergic pathways mediate object recognition memory in the monkey SOR task.
format Artigo
author Oliveira, André Wagner Carvalho de
Pacheco, Jéssica V. N.
Costa, Clara de Sena
Aquino, Jéssica
Maior, Rafael Plakoudi Souto
Barros, Marilia
author_sort Oliveira, André Wagner Carvalho de
title Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
title_short Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
title_full Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
title_fullStr Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
title_full_unstemmed Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
title_sort scopolamine and mk-801 impair recognition memory in a new spontaneous object exploration task in monkeys
publisher Elsevier Inc.
publishDate 2021
url https://repositorio.unb.br/handle/10482/42452
https://doi.org/10.1016/j.pbb.2021.173300
_version_ 1721216632314920960
score 13.657419

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