New prospects in neutering male animals using magnetic nanoparticle hyperthermia
Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs sp...
| Main Authors: | Jivago, José Luiz P. R., Brito, Juliana Lis Mendes, Capistrano, Gustavo, Araújo, Marcus Vinícius, Verde, Ediron Lima, Bakuzis, Andris Figueiroa, Souza, Paulo E. N., Azevedo, Ricardo Bentes, Lucci, Carolina Madeira |
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| Language: | Inglês |
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MDPI
2021
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https://repositorio.unb.br/handle/10482/42547 https://doi.org/10.3390/pharmaceutics13091465 https://orcid.org/ 0000-0002-6326-9803 https://orcid.org/ 0000-0002-2137-9588 https://orcid.org/ 0000-0001-7763-0746 |
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ir-10482-425472021-12-07T16:15:42Z New prospects in neutering male animals using magnetic nanoparticle hyperthermia Jivago, José Luiz P. R. Brito, Juliana Lis Mendes Capistrano, Gustavo Araújo, Marcus Vinícius Verde, Ediron Lima Bakuzis, Andris Figueiroa Souza, Paulo E. N. Azevedo, Ricardo Bentes Lucci, Carolina Madeira Castração Infertilidade Testículos Espermatogênese Hipertermia Nanopartículas magnéticas Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs spermatogenesis, the present study investigated localized application of magnetic nanoparticle hyperthermia (MNH) to the testicles as a potential non-surgical sterilization method for animals. An intratesticular injection of a magnetic fluid composed of manganese-ferrite nanoparticles functionalized with citrate was administered followed by testicle exposure to an alternate magnetic field to generate localized heat. Testicular MNH was highly effective, causing progressive seminiferous tubule degeneration followed by substitution of the parenchyma with stromal tissue and gonadal atrophy, suggesting an irreversible process with few side effects to general animal health. 2021-12-07T16:15:42Z 2021-12-07T16:15:42Z 2021-09-14 Artigo JIVAGO, José Luiz P. R. et al. New prospects in neutering male animals using magnetic nanoparticle hyperthermia. Pharmaceutics, [S.l.], v. 13, n. 9, 1465, 2021. DOI: https://doi.org/10.3390/pharmaceutics13091465. Disponível em: https://www.mdpi.com/1999-4923/13/9/1465. Acesso em: 05 dez. 2021. https://repositorio.unb.br/handle/10482/42547 https://doi.org/10.3390/pharmaceutics13091465 https://orcid.org/ 0000-0002-6326-9803 https://orcid.org/ 0000-0002-2137-9588 https://orcid.org/ 0000-0001-7763-0746 Inglês Acesso Aberto Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf MDPI |
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Inglês |
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Castração Infertilidade Testículos Espermatogênese Hipertermia Nanopartículas magnéticas |
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Castração Infertilidade Testículos Espermatogênese Hipertermia Nanopartículas magnéticas Jivago, José Luiz P. R. Brito, Juliana Lis Mendes Capistrano, Gustavo Araújo, Marcus Vinícius Verde, Ediron Lima Bakuzis, Andris Figueiroa Souza, Paulo E. N. Azevedo, Ricardo Bentes Lucci, Carolina Madeira New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| description |
Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs spermatogenesis, the present study investigated localized application of magnetic nanoparticle hyperthermia (MNH) to the testicles as a potential non-surgical sterilization method for animals. An intratesticular injection of a magnetic fluid composed of manganese-ferrite nanoparticles functionalized with citrate was administered followed by testicle exposure to an alternate magnetic field to generate localized heat. Testicular MNH was highly effective, causing progressive seminiferous tubule degeneration followed by substitution of the parenchyma with stromal tissue and gonadal atrophy, suggesting an irreversible process with few side effects to general animal health. |
| format |
Artigo |
| author |
Jivago, José Luiz P. R. Brito, Juliana Lis Mendes Capistrano, Gustavo Araújo, Marcus Vinícius Verde, Ediron Lima Bakuzis, Andris Figueiroa Souza, Paulo E. N. Azevedo, Ricardo Bentes Lucci, Carolina Madeira |
| author_sort |
Jivago, José Luiz P. R. |
| title |
New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| title_short |
New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| title_full |
New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| title_fullStr |
New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| title_full_unstemmed |
New prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| title_sort |
new prospects in neutering male animals using magnetic nanoparticle hyperthermia |
| publisher |
MDPI |
| publishDate |
2021 |
| url |
https://repositorio.unb.br/handle/10482/42547 https://doi.org/10.3390/pharmaceutics13091465 https://orcid.org/ 0000-0002-6326-9803 https://orcid.org/ 0000-0002-2137-9588 https://orcid.org/ 0000-0001-7763-0746 |
| _version_ |
1721216634517979136 |
| score |
13.657419 |