Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most p...
| Main Authors: | Cruz, Márcio R, Cerqueira, Daniela M, Cruz, Waldenor B, Camara, Geni NL, Brígido, Marcelo de Macedo, Silva, Evandro O, Carvalho, Luciano GS, Martins, Cláudia RF |
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| Format: | Artigo |
| Language: | English |
| Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
2017
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| Subjects: | |
| Online Access: |
http://repositorio.unb.br/handle/10482/26144 |
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| Summary: |
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma. |
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