Impact of a chromosome X STR Decaplex in deficiency paternity cases

Deficiency paternity cases, characterized by the absence of the alleged father, are a challenge for forensic genetics. Here we present four cases with a female child and a deceased alleged father in which the analysis of a set of 21 or 22 autosomal STRs (AS STRs) produced results within a range of d...

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Main Authors: Trindade Filho, Aluisio, Ferreira, Samuel, Oliveira, Silviene Fabiana de
Format: Artigo
Language: English
Published: Sociedade Brasileira de Genética 2017
Subjects:
Online Access: http://repositorio.unb.br/handle/10482/28964
https://dx.doi.org/10.1590/S1415-47572013000400008
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Summary: Deficiency paternity cases, characterized by the absence of the alleged father, are a challenge for forensic genetics. Here we present four cases with a female child and a deceased alleged father in which the analysis of a set of 21 or 22 autosomal STRs (AS STRs) produced results within a range of doubt when genotyping relatives of the alleged father. Aiming to increase the Paternity Index (PI) and obtain more reliable results, a set of 10 X-linked STR markers, developed by the Spanish and Portuguese Group of the International Society for Forensic Genetics (ISFG), was then added. Statistical analysis substantially shifted the results towards the alleged fatherhood in all four cases, with more dramatic changes when the supposed half-sister and respective mother were the relatives tested.