Staff View: The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females

The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females

Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to bio...

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Main Authors:	Roll, Mariana Matos, Vilela, Ana Luísa Miranda, Longo, João Paulo Figueiró, Agostini-Costa, Tânia da Silveira, Grisolia, Cesar Koppe
Format:	Artigo
Language:	English
Published:	Sociedade Brasileira de Genética 2019
Subjects:	Inflamação - envelhecimento Stress oxidativo Antioxidantes Medicina popular
Online Access:	http://repositorio.unb.br/handle/10482/33562 http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218
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spelling	ir-10482-335622019-01-31T09:34:03Z The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females Roll, Mariana Matos Vilela, Ana Luísa Miranda Longo, João Paulo Figueiró Agostini-Costa, Tânia da Silveira Grisolia, Cesar Koppe Inflamação - envelhecimento Stress oxidativo Antioxidantes Medicina popular Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage in healthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, were orally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, and bone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin and hematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oil had no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+monocytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12 months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammation and oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females. 2019-01-02T13:53:55Z 2019-01-02T13:53:55Z 2018 Artigo ROLL, Mariana Matos et al . The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females. Genet. Mol. Biol., Ribeirão Preto , v. 41, n. 4, p. 858-869, Dec. 2018 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500858&lng=en&nrm=iso>. access on 30 Jan. 2019. Epub Nov 29, 2018. http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218. http://repositorio.unb.br/handle/10482/33562 http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218 en Acesso Aberto License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. application/pdf Sociedade Brasileira de Genética
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	English
topic	Inflamação - envelhecimento Stress oxidativo Antioxidantes Medicina popular
spellingShingle	Inflamação - envelhecimento Stress oxidativo Antioxidantes Medicina popular Roll, Mariana Matos Vilela, Ana Luísa Miranda Longo, João Paulo Figueiró Agostini-Costa, Tânia da Silveira Grisolia, Cesar Koppe The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
description	Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage in healthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, were orally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, and bone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin and hematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oil had no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+monocytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12 months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammation and oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females.
format	Artigo
author	Roll, Mariana Matos Vilela, Ana Luísa Miranda Longo, João Paulo Figueiró Agostini-Costa, Tânia da Silveira Grisolia, Cesar Koppe
author_sort	Roll, Mariana Matos
title	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_short	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_full	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_fullStr	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_full_unstemmed	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
title_sort	pequi pulp oil (caryocar brasiliense camb.) provides protection against aging-related anemia, inflammation and oxidative stress in swiss mice, especially in females
publisher	Sociedade Brasileira de Genética
publishDate	2019
url	http://repositorio.unb.br/handle/10482/33562 http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218
_version_	1641988791684038656
score	13.657419

The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females

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