The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier...
| Main Authors: | Morais, Rafael Martins de, Barra Sobrinho, Alaor, Silva, Calliandra Maria de Souza, Oliveira, Jamila Reis de, Silva, Izabel Cristina Rodrigues da, Nóbrega, Otávio de Toledo |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Hindawi
2019
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| Subjects: | |
| Online Access: |
http://repositorio.unb.br/handle/10482/34070 https://doi.org/10.1155/2018/9128754 |
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| Summary: |
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. |
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