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The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review

Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier...

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Main Authors: Morais, Rafael Martins de, Barra Sobrinho, Alaor, Silva, Calliandra Maria de Souza, Oliveira, Jamila Reis de, Silva, Izabel Cristina Rodrigues da, Nóbrega, Otávio de Toledo
Format: Artigo
Language: Inglês
Published: Hindawi 2019
Subjects:
Tireóide - câncer
Online Access: http://repositorio.unb.br/handle/10482/34070
https://doi.org/10.1155/2018/9128754
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spelling ir-10482-340702019-02-27T10:58:00Z The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review Morais, Rafael Martins de Barra Sobrinho, Alaor Silva, Calliandra Maria de Souza Oliveira, Jamila Reis de Silva, Izabel Cristina Rodrigues da Nóbrega, Otávio de Toledo Tireóide - câncer Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. 2019-02-25T14:36:56Z 2019-02-25T14:36:56Z 2018-11 Artigo MORAIS, Rafael Martins de et al. The role of the NIS (SLC5A5) gene in Papillary thyroid cancer: a systematic review. International Journal of Endocrinology, v. 2018, Article ID 9128754, 11 p. DOI: https://doi.org/10.1155/2018/9128754. Disponível em: https://www.hindawi.com/journals/ije/2018/9128754/. Acesso em: 25 fev. 2019. http://repositorio.unb.br/handle/10482/34070 https://doi.org/10.1155/2018/9128754 Inglês Acesso Aberto Copyright © 2018 Rafael Martins de Morais et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi
institution REPOSITORIO UNB
collection REPOSITORIO UNB
language Inglês
topic Tireóide - câncer
spellingShingle Tireóide - câncer
Morais, Rafael Martins de
Barra Sobrinho, Alaor
Silva, Calliandra Maria de Souza
Oliveira, Jamila Reis de
Silva, Izabel Cristina Rodrigues da
Nóbrega, Otávio de Toledo
The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
description Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.
format Artigo
author Morais, Rafael Martins de
Barra Sobrinho, Alaor
Silva, Calliandra Maria de Souza
Oliveira, Jamila Reis de
Silva, Izabel Cristina Rodrigues da
Nóbrega, Otávio de Toledo
author_sort Morais, Rafael Martins de
title The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
title_short The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
title_full The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
title_fullStr The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
title_full_unstemmed The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
title_sort role of the nis (slc5a5) gene in papillary thyroid cancer : a systematic review
publisher Hindawi
publishDate 2019
url http://repositorio.unb.br/handle/10482/34070
https://doi.org/10.1155/2018/9128754
_version_ 1641988230068830208
score 13.657419

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