Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired...
| Main Authors: | Neves, Juliete Silva, Silva, Zita Lopes da, Brito Neta, Maria de Sousa, Chaves, Sacha Braun, Nóbrega, Yanna Karla de Medeiros, Machado, Angelo Henrique de Lira, Silva, Fabricio Machado |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Royal Society of Chemistry
2019
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| Subjects: | |
| Online Access: |
https://repositorio.unb.br/handle/10482/35912 https://orcid.org/0000-0003-4284-9929 https://orcid.org/0000-0002-3041-1906 |
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| Summary: |
The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural
preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is
a technique used to protect it, minimizing degradation and reducing undesired interaction with the other
formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing
essential oil from Rosmarinus officinalis, aiming to use it as an antifungal component in cosmetics. The
capsules were obtained via terpolymerization of methyl methacrylate, styrene and methacrylic acid in
a dispersed phase polymerization process. The properties of the polymers and the fungicide activity
were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging
from 2.25 to 4.5 mg mL 1 and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL 1 for
strains of Candida albicans, Candida glabrata and Candida parapsilosis, and after the encapsulation
process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against
fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing
Rosmarinus officinalis essential oil can be regarded as a very promising material intended for cosmetics
and drug delivery applications. |
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