Staff View: Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity

Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity

The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired...

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Main Authors:	Neves, Juliete Silva, Silva, Zita Lopes da, Brito Neta, Maria de Sousa, Chaves, Sacha Braun, Nóbrega, Yanna Karla de Medeiros, Machado, Angelo Henrique de Lira, Silva, Fabricio Machado
Format:	Artigo
Language:	Inglês
Published:	The Royal Society of Chemistry 2019
Subjects:	Alecrim Essências e óleos essenciais Cápsulas (Farmácia) Antimicóticos
Online Access:	https://repositorio.unb.br/handle/10482/35912 https://orcid.org/0000-0003-4284-9929 https://orcid.org/0000-0002-3041-1906
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spelling	ir-10482-359122020-05-06T13:16:42Z Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity Neves, Juliete Silva Silva, Zita Lopes da Brito Neta, Maria de Sousa Chaves, Sacha Braun Nóbrega, Yanna Karla de Medeiros Machado, Angelo Henrique de Lira Silva, Fabricio Machado Alecrim Essências e óleos essenciais Cápsulas (Farmácia) Antimicóticos The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired interaction with the other formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing essential oil from Rosmarinus officinalis, aiming to use it as an antifungal component in cosmetics. The capsules were obtained via terpolymerization of methyl methacrylate, styrene and methacrylic acid in a dispersed phase polymerization process. The properties of the polymers and the fungicide activity were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging from 2.25 to 4.5 mg mL 1 and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL 1 for strains of Candida albicans, Candida glabrata and Candida parapsilosis, and after the encapsulation process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing Rosmarinus officinalis essential oil can be regarded as a very promising material intended for cosmetics and drug delivery applications. 2019-12-05T14:25:13Z 2019-12-05T14:25:13Z 2019-07 Artigo NEVES, Juliete Silva et al. Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity. RSC Advances, v. 9, 22586, 2019. DOI: 10.1039/c9ra02336d. Disponível em: https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra02336d#!divAbstract. Acesso em: 05 dez. 2019. https://repositorio.unb.br/handle/10482/35912 10.1039/c9ra02336d https://orcid.org/0000-0003-4284-9929 https://orcid.org/0000-0002-3041-1906 Inglês Acesso Aberto (CC BY NC) - This article is licensed under Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf The Royal Society of Chemistry
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Alecrim Essências e óleos essenciais Cápsulas (Farmácia) Antimicóticos
spellingShingle	Alecrim Essências e óleos essenciais Cápsulas (Farmácia) Antimicóticos Neves, Juliete Silva Silva, Zita Lopes da Brito Neta, Maria de Sousa Chaves, Sacha Braun Nóbrega, Yanna Karla de Medeiros Machado, Angelo Henrique de Lira Silva, Fabricio Machado Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
description	The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired interaction with the other formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing essential oil from Rosmarinus officinalis, aiming to use it as an antifungal component in cosmetics. The capsules were obtained via terpolymerization of methyl methacrylate, styrene and methacrylic acid in a dispersed phase polymerization process. The properties of the polymers and the fungicide activity were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging from 2.25 to 4.5 mg mL 1 and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL 1 for strains of Candida albicans, Candida glabrata and Candida parapsilosis, and after the encapsulation process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing Rosmarinus officinalis essential oil can be regarded as a very promising material intended for cosmetics and drug delivery applications.
format	Artigo
author	Neves, Juliete Silva Silva, Zita Lopes da Brito Neta, Maria de Sousa Chaves, Sacha Braun Nóbrega, Yanna Karla de Medeiros Machado, Angelo Henrique de Lira Silva, Fabricio Machado
author_sort	Neves, Juliete Silva
title	Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
title_short	Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
title_full	Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
title_fullStr	Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
title_full_unstemmed	Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity
title_sort	preparation of terpolymer capsules containing rosmarinus officinalis essential oil and evaluation of its antifungal activity
publisher	The Royal Society of Chemistry
publishDate	2019
url	https://repositorio.unb.br/handle/10482/35912 https://orcid.org/0000-0003-4284-9929 https://orcid.org/0000-0002-3041-1906
_version_	1672205502208016384
score	13.657419

Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity

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