Staff View: Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines

Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines

Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid p...

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Main Authors:	Tauil, Carlos Bernardo, Lima, Amanda D. da Rocha, Ferrari, Breno B., Silva, Veronica A. G. da, Moraes, Adriel S., Silva, Flavia M. da, Silva, Cesar A. Melo, Farias, Alessandro S., Brandão, Carlos O., Santos, Leonilda M. B. dos, Santos Neto, Leopoldo Luiz dos
Format:	Artigo
Language:	Inglês
Published:	Elsevier Inc. 2020
Subjects:	Depressão mental Ansiedade Inflamação Esclerose múltipla Indoleamina 2,3-dioxigenase Citocinas
Online Access:	https://repositorio.unb.br/handle/10482/39610 https://doi.org/10.1016/j.bbih.2020.100162
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spelling	ir-10482-396102020-11-05T16:38:04Z Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines Tauil, Carlos Bernardo Lima, Amanda D. da Rocha Ferrari, Breno B. Silva, Veronica A. G. da Moraes, Adriel S. Silva, Flavia M. da Silva, Cesar A. Melo Farias, Alessandro S. Brandão, Carlos O. Santos, Leonilda M. B. dos Santos Neto, Leopoldo Luiz dos Depressão mental Ansiedade Inflamação Esclerose múltipla Indoleamina 2,3-dioxigenase Citocinas Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid precursor of serotonin and melatonin. It has been suggested that IDO is the link between the immune and serotonergic systems. This study aimed to quantify the levels of IDO and pro-inflammatory and anti-inflammatory cytokines in patients with MS and depression, according to treatment with interferon-beta (IFN-β) or fingolimod. The study inclusion criteria were age 18–60 years and a clinical and radiological diagnosis of MS. One hundred and thirtytwo patients diagnosed by McDonald’s criteria and followed up at Brasília District Hospital, Brazil, with relapsingremitting MS were identified as potential study participants. Thirty-five of these patients were identified to be receiving treatment with fingolimod or IFN-β and to have a diagnosis of D/A. IDO and pro-inflammatory and antiinflammatory cytokine levels were compared between these 35 patients and 18 healthy controls. The level of IL10 (an anti-inflammatory cytokine) was lower in both the fingolimod-treated (P < 0.001) and IFN-β-treated (P < 0.01) patient groups than in the control group. IFN-β-treated patients showed increased IDO expression and decreased inflammatory cytokine levels. In contrast, fingolimod-treated patients showed significantly decreased expression of IDO and significantly increased levels of proinflammatory cytokines produced by innate immune cells, including tumor necrosis factor-alpha and interleukin-6. The agents used to treat MS maintain symptoms of D/A in patients with MS via different mechanisms. 2020-11-05T16:38:04Z 2020-11-05T16:38:04Z 2020-10-23 Artigo TAUIL, Carlos B. et al. Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod: role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines. Brain, Behavior, & Immunity - Health, v. 9, 100162, dez 2020. DOI: https://doi.org/10.1016/j.bbih.2020.100162. Disponível em: https://www.sciencedirect.com/science/article/pii/S2666354620301277?via%3Dihub. Acesso em: 05 nov. 2020. https://repositorio.unb.br/handle/10482/39610 https://doi.org/10.1016/j.bbih.2020.100162 Inglês Acesso Aberto © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). application/pdf Elsevier Inc.
institution	REPOSITORIO UNB
collection	REPOSITORIO UNB
language	Inglês
topic	Depressão mental Ansiedade Inflamação Esclerose múltipla Indoleamina 2,3-dioxigenase Citocinas
spellingShingle	Depressão mental Ansiedade Inflamação Esclerose múltipla Indoleamina 2,3-dioxigenase Citocinas Tauil, Carlos Bernardo Lima, Amanda D. da Rocha Ferrari, Breno B. Silva, Veronica A. G. da Moraes, Adriel S. Silva, Flavia M. da Silva, Cesar A. Melo Farias, Alessandro S. Brandão, Carlos O. Santos, Leonilda M. B. dos Santos Neto, Leopoldo Luiz dos Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
description	Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid precursor of serotonin and melatonin. It has been suggested that IDO is the link between the immune and serotonergic systems. This study aimed to quantify the levels of IDO and pro-inflammatory and anti-inflammatory cytokines in patients with MS and depression, according to treatment with interferon-beta (IFN-β) or fingolimod. The study inclusion criteria were age 18–60 years and a clinical and radiological diagnosis of MS. One hundred and thirtytwo patients diagnosed by McDonald’s criteria and followed up at Brasília District Hospital, Brazil, with relapsingremitting MS were identified as potential study participants. Thirty-five of these patients were identified to be receiving treatment with fingolimod or IFN-β and to have a diagnosis of D/A. IDO and pro-inflammatory and antiinflammatory cytokine levels were compared between these 35 patients and 18 healthy controls. The level of IL10 (an anti-inflammatory cytokine) was lower in both the fingolimod-treated (P < 0.001) and IFN-β-treated (P < 0.01) patient groups than in the control group. IFN-β-treated patients showed increased IDO expression and decreased inflammatory cytokine levels. In contrast, fingolimod-treated patients showed significantly decreased expression of IDO and significantly increased levels of proinflammatory cytokines produced by innate immune cells, including tumor necrosis factor-alpha and interleukin-6. The agents used to treat MS maintain symptoms of D/A in patients with MS via different mechanisms.
format	Artigo
author	Tauil, Carlos Bernardo Lima, Amanda D. da Rocha Ferrari, Breno B. Silva, Veronica A. G. da Moraes, Adriel S. Silva, Flavia M. da Silva, Cesar A. Melo Farias, Alessandro S. Brandão, Carlos O. Santos, Leonilda M. B. dos Santos Neto, Leopoldo Luiz dos
author_sort	Tauil, Carlos Bernardo
title	Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
title_short	Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
title_full	Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
title_fullStr	Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
title_full_unstemmed	Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
title_sort	depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines
publisher	Elsevier Inc.
publishDate	2020
url	https://repositorio.unb.br/handle/10482/39610 https://doi.org/10.1016/j.bbih.2020.100162
_version_	1683063394597339136
score	13.657419

Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod : role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines

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